Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells

BACKGROUND: KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. To date, there are still no target-specific vaccines or drugs available against this genotype, thus reinforcing the need towards the development of target...

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Detalles Bibliográficos
Autores principales: Teo, Michelle Yee Mun, Ng, Jeremy Jeack Ceen, Fong, Jung Yin, Hwang, Jung Shan, Song, Adelene Ai-Lian, Lim, Renee Lay Hong, In, Lionel Lian Aun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053384/
https://www.ncbi.nlm.nih.gov/pubmed/33959410
http://dx.doi.org/10.7717/peerj.11063

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