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The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer
OBJECTIVES: We investigated the relationship between tumor characteristics and visible tumors on magnetic resonance imaging (MRI) and examined the prognosis of tumor detection on MRI compared with no tumor detection in localized prostate cancer. MATERIALS AND METHODS: We reviewed 214 patients with p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Pacific Prostate Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053693/ https://www.ncbi.nlm.nih.gov/pubmed/33912508 http://dx.doi.org/10.1016/j.prnil.2020.06.001 |
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author | Shin, Teak Jun Jung, Wonho Ha, Ji Yong Kim, Byung Hoon Kim, Young Hwan |
author_facet | Shin, Teak Jun Jung, Wonho Ha, Ji Yong Kim, Byung Hoon Kim, Young Hwan |
author_sort | Shin, Teak Jun |
collection | PubMed |
description | OBJECTIVES: We investigated the relationship between tumor characteristics and visible tumors on magnetic resonance imaging (MRI) and examined the prognosis of tumor detection on MRI compared with no tumor detection in localized prostate cancer. MATERIALS AND METHODS: We reviewed 214 patients with pT2N0M0 prostate cancer who underwent radical prostatectomy between January 2009 and December 2016. All the patients underwent MRI preoperatively. The patients were divided into 2 groups postoperatively: no visible tumor on the MRI group (n = 96, 44.9%) and visible tumor on the MRI group (n = 118, 55.1%). The visible tumor was defined as Prostate Imaging Reporting and Data System, version 2 Grade ≥ 3 on MRI. Age, prostate-specific antigen, prostate volume, positive surgical margin (PSM), lymphovascular invasion, and biochemical recurrence (BCR) were compared between the 2 groups. We also assessed the relationship between visible tumors on MRI and oncologic characteristics. RESULTS: The visible tumor on the MRI group showed a higher Gleason score ≥4 + 3 [45.8% versus (vs.) 17.7%], high frequency of postoperative PSMs (28.8% vs. 16.7%), and higher BCR rate (17.8% vs. 7.3%) than the no visible tumor on the MRI group. The Kaplan–Meier analysis for BCR-free survival also showed a significant difference (P = 0.006). In multivariate Cox regression analysis, the detection of tumors on MRI was associated with a higher BCR risk [hazard ratio: 3.35; 95% confidence interval (CI): 1.36-8.27; P = 0.009]. We found a positive association between visible tumors on MRI and primary Gleason pattern of ≥4 (odds ratio: 4.31; 95% CI: 2.21–8.40; P < 0.001). CONCLUSIONS: In localized prostate cancer, BCR was significantly more frequent when the tumor was detected on MRI, and a visible tumor on MRI was associated with the Gleason score. Therefore, attention should be paid to the possibility of high-grade prostate cancer when a tumor is detected on MRI before radical prostatectomy, and active follow-up may be needed postoperatively. |
format | Online Article Text |
id | pubmed-8053693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Asian Pacific Prostate Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-80536932021-04-27 The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer Shin, Teak Jun Jung, Wonho Ha, Ji Yong Kim, Byung Hoon Kim, Young Hwan Prostate Int Research Article OBJECTIVES: We investigated the relationship between tumor characteristics and visible tumors on magnetic resonance imaging (MRI) and examined the prognosis of tumor detection on MRI compared with no tumor detection in localized prostate cancer. MATERIALS AND METHODS: We reviewed 214 patients with pT2N0M0 prostate cancer who underwent radical prostatectomy between January 2009 and December 2016. All the patients underwent MRI preoperatively. The patients were divided into 2 groups postoperatively: no visible tumor on the MRI group (n = 96, 44.9%) and visible tumor on the MRI group (n = 118, 55.1%). The visible tumor was defined as Prostate Imaging Reporting and Data System, version 2 Grade ≥ 3 on MRI. Age, prostate-specific antigen, prostate volume, positive surgical margin (PSM), lymphovascular invasion, and biochemical recurrence (BCR) were compared between the 2 groups. We also assessed the relationship between visible tumors on MRI and oncologic characteristics. RESULTS: The visible tumor on the MRI group showed a higher Gleason score ≥4 + 3 [45.8% versus (vs.) 17.7%], high frequency of postoperative PSMs (28.8% vs. 16.7%), and higher BCR rate (17.8% vs. 7.3%) than the no visible tumor on the MRI group. The Kaplan–Meier analysis for BCR-free survival also showed a significant difference (P = 0.006). In multivariate Cox regression analysis, the detection of tumors on MRI was associated with a higher BCR risk [hazard ratio: 3.35; 95% confidence interval (CI): 1.36-8.27; P = 0.009]. We found a positive association between visible tumors on MRI and primary Gleason pattern of ≥4 (odds ratio: 4.31; 95% CI: 2.21–8.40; P < 0.001). CONCLUSIONS: In localized prostate cancer, BCR was significantly more frequent when the tumor was detected on MRI, and a visible tumor on MRI was associated with the Gleason score. Therefore, attention should be paid to the possibility of high-grade prostate cancer when a tumor is detected on MRI before radical prostatectomy, and active follow-up may be needed postoperatively. Asian Pacific Prostate Society 2021-03 2020-06-26 /pmc/articles/PMC8053693/ /pubmed/33912508 http://dx.doi.org/10.1016/j.prnil.2020.06.001 Text en © 2020 Asian Pacific Prostate Society. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Shin, Teak Jun Jung, Wonho Ha, Ji Yong Kim, Byung Hoon Kim, Young Hwan The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
title | The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
title_full | The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
title_fullStr | The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
title_full_unstemmed | The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
title_short | The significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
title_sort | significance of the visible tumor on preoperative magnetic resonance imaging in localized prostate cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053693/ https://www.ncbi.nlm.nih.gov/pubmed/33912508 http://dx.doi.org/10.1016/j.prnil.2020.06.001 |
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