The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer

Colorectal cancer (CRC) is one of the most common types of cancers. It is associated with a poor prognosis and high mortality. The role of mucins (MUCs) in colon tumorigenesis is unclear, but it might be significant in the progression of malignancy. Some mucins, such as MUC1 and MUC13, act as oncoge...

Descripción completa

Detalles Bibliográficos
Autor principal: Almasmoum, Hussain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053700/
https://www.ncbi.nlm.nih.gov/pubmed/33883940
http://dx.doi.org/10.2147/CMAR.S299089
_version_ 1783680172168314880
author Almasmoum, Hussain
author_facet Almasmoum, Hussain
author_sort Almasmoum, Hussain
collection PubMed
description Colorectal cancer (CRC) is one of the most common types of cancers. It is associated with a poor prognosis and high mortality. The role of mucins (MUCs) in colon tumorigenesis is unclear, but it might be significant in the progression of malignancy. Some mucins, such as MUC1 and MUC13, act as oncogenes, whereas others, such as MUC2 and MUC6, are tumor suppressors. However, there are still mucins with unidentified roles in CRC. In this review, we discuss the reported roles of mucins in CRC. Moreover, we review the capability of the mucin family to serve as a sensitive and specific histopathological marker for the early diagnosis of CRC. Lastly, the role of mucin genes clustered on chromosome 7q22 in CRC and other cancers is also discussed.
format Online
Article
Text
id pubmed-8053700
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-80537002021-04-20 The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer Almasmoum, Hussain Cancer Manag Res Review Colorectal cancer (CRC) is one of the most common types of cancers. It is associated with a poor prognosis and high mortality. The role of mucins (MUCs) in colon tumorigenesis is unclear, but it might be significant in the progression of malignancy. Some mucins, such as MUC1 and MUC13, act as oncogenes, whereas others, such as MUC2 and MUC6, are tumor suppressors. However, there are still mucins with unidentified roles in CRC. In this review, we discuss the reported roles of mucins in CRC. Moreover, we review the capability of the mucin family to serve as a sensitive and specific histopathological marker for the early diagnosis of CRC. Lastly, the role of mucin genes clustered on chromosome 7q22 in CRC and other cancers is also discussed. Dove 2021-04-14 /pmc/articles/PMC8053700/ /pubmed/33883940 http://dx.doi.org/10.2147/CMAR.S299089 Text en © 2021 Almasmoum. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Almasmoum, Hussain
The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
title The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
title_full The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
title_fullStr The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
title_full_unstemmed The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
title_short The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
title_sort roles of transmembrane mucins located on chromosome 7q22.1 in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053700/
https://www.ncbi.nlm.nih.gov/pubmed/33883940
http://dx.doi.org/10.2147/CMAR.S299089
work_keys_str_mv AT almasmoumhussain therolesoftransmembranemucinslocatedonchromosome7q221incolorectalcancer
AT almasmoumhussain rolesoftransmembranemucinslocatedonchromosome7q221incolorectalcancer

Ejemplares similares