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Cotranscriptional R-loop formation by Mfd involves topological partitioning of DNA

R-loops are nucleic acid hybrids which form when an RNA invades duplex DNA to pair with its template sequence. Although they are implicated in a growing number of gene regulatory processes, their mechanistic origins remain unclear. We here report real-time observations of cotranscriptional R-loop fo...

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Detalles Bibliográficos
Autores principales: Portman, James R., Brouwer, Gwendolyn M., Bollins, Jack, Savery, Nigel J., Strick, Terence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053947/
https://www.ncbi.nlm.nih.gov/pubmed/33827922
http://dx.doi.org/10.1073/pnas.2019630118