Cargando…

A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial

OBJECTIVES: The primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin®(plasma-purified alpha-1 antitrypsin) reduces circulating plasma levels of i...

Descripción completa

Detalles Bibliográficos
Autores principales:	McEvoy, Natalie L., Clarke, Jennifer L., Mc Elvaney, Oliver J., Mc Elvaney, Oisin F., Boland, Fiona, Hyland, Deirdre, Geoghegan, Pierce, Donnelly, Karen, Friel, Oisin, Cullen, Ailbhe, Collins, Ann M., Fraughen, Daniel, Martin-Loeches, Ignacio, Hennessy, Martina, Laffey, John G., Mc Elvaney, Noel G., Curley, Gerard F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054126/ https://www.ncbi.nlm.nih.gov/pubmed/33874981 http://dx.doi.org/10.1186/s13063-021-05254-0

Ejemplares similares

A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19
por: McElvaney, Oliver J., et al.
Publicado: (2022)

Alpha-1 antitrypsin for cystic fibrosis complicated by severe cytokinemic COVID-19
por: McElvaney, Oliver J, et al.
Publicado: (2021)

Prone positioning improves oxygenation and lung recruitment in patients with SARS-CoV-2 acute respiratory distress syndrome; a single centre cohort study of 20 consecutive patients
por: Clarke, Jennifer, et al.
Publicado: (2021)

Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients
por: Palmas, Francesco, et al.
Publicado: (2021)

A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19
por: McElvaney, Oliver J, et al.
Publicado: (2020)

Corrigendum to ‘A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19’
por: McElvaney, Oliver J, et al.
Publicado: (2020)

Reply to Blot et al. and to Inoue et al.
por: McElvaney, Oliver J., et al.
Publicado: (2021)

Diagnosing α(1)-antitrypsin deficiency: how to improve the current algorithm
por: McElvaney, Noel G.
Publicado: (2015)

Is There a Therapeutic Role for Selenium in Alpha-1 Antitrypsin Deficiency?
por: Greene, Catherine M., et al.
Publicado: (2013)

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency
por: McLean, Caitriona, et al.
Publicado: (2009)

The prevalence of liver abnormalities in individuals with ZZ Alpha-1 Antitrypsin deficiency
por: McElvaney, OF, et al.
Publicado: (2015)

Interleukin-6: obstacles to targeting a complex cytokine in critical illness
por: McElvaney, Oliver J, et al.
Publicado: (2021)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Emotion-focused therapy as a transdiagnostic treatment for depression, anxiety and related disorders: Protocol for an initial feasibility randomised control trial
por: Timulak, Ladislav, et al.
Publicado: (2020)

Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes
por: Chotirmall, Sanjay H, et al.
Publicado: (2015)

Alpha-1 antitrypsin regulates neutrophil reactive oxygen species production via inhibition of key players of the respiratory burst oxidase system
por: Alfawaz, Bader, et al.
Publicado: (2013)

Dysregulated neutrophil function in individuals with alpha-1 antitrypsin deficiency caused by modified membrane cholesterol content.
por: Jundi, Bakr, et al.
Publicado: (2015)

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals
por: Dunlea, Danielle M, et al.
Publicado: (2018)

Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency
por: O'Brien, Michael E, et al.
Publicado: (2020)

Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications
por: McElvaney, Oisin F., et al.
Publicado: (2022)

Pressure ulcers in patients with COVID‐19 acute respiratory distress syndrome undergoing prone positioning in the intensive care unit: A pre‐ and post‐intervention study
por: McEvoy, Natalie L., et al.
Publicado: (2022)

Clinical considerations in individuals with α(1)-antitrypsin PI*SZ genotype
por: McElvaney, Gerard N., et al.
Publicado: (2020)

Adult and Adolescent Disclosures of Child Sexual Abuse: A Comparative Analysis
por: McGill, Lucy, et al.
Publicado: (2022)

Physical Activity, Exercise Capacity and Sedentary Behavior in People with Alpha-1 Antitrypsin Deficiency: A Scoping Review
por: O’Shea, Orlagh, et al.
Publicado: (2023)

Spectral Tuning of a Nanoparticle-on-Mirror System by Graphene Doping and Gap Control with Nitric Acid
por: Lawless, Julia, et al.
Publicado: (2023)

Safety of biweekly α(1)-antitrypsin treatment in the RAPID programme
por: Greulich, Timm, et al.
Publicado: (2018)

Characterization of the Inflammatory Response to Severe COVID-19 Illness
por: McElvaney, Oliver J., et al.
Publicado: (2020)

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals
por: Hawkins, Padraig, et al.
Publicado: (2021)

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB
por: Hassan, Tidi, et al.
Publicado: (2017)

The prevalence of alpha-1 antitrypsin deficiency in Ireland
por: Carroll, Tomás P, et al.
Publicado: (2011)

Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis
por: McQuillan, Karen, et al.
Publicado: (2020)

The effect of exacerbations on lung density in α(1)-antitrypsin deficiency
por: Strange, Charlie, et al.
Publicado: (2023)

A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application
por: O’Brien, Michael E., et al.
Publicado: (2022)

The importance of CFTR expression for neutrophil function in patients with Cystic Fibrosis
por: Jundi, B, et al.
Publicado: (2015)

Perceiving threat in others: The role of body morphology
por: McElvaney, Terence J., et al.
Publicado: (2021)

Identifying criminals: No biasing effect of criminal context on recalled threat
por: McElvaney, Terence J., et al.
Publicado: (2022)

Coeliac disease: clinical presentations, correlations of dietary compliance, symptomatic response and repeat biopsy findings.
por: McElvaney, N. G., et al.
Publicado: (1992)

An investigation of IL-8 degradation in response to PA401 compared to hypertonic saline in bronchoalveolar lavage fluid of Cystic Fibrosis patients
por: Kerr, H, et al.
Publicado: (2015)

Adolescents’ experiences of psychotherapy following child sexual abuse
por: McElvaney, Rosaleen, et al.
Publicado: (2023)

In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α(1)-antitrypsin
por: Hawkins, Padraig, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eo721c55trutpgfftjtqp334kp