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The molecular basis of the inhibition of Ca(V)1 calcium-dependent inactivation by the distal carboxy tail

Ca(2+)/calmodulin-dependent inactivation (CDI) of Ca(V) channels is a critical regulatory process that tunes the kinetics of Ca(2+) entry for different cell types and physiologic responses. CDI is mediated by calmodulin (CaM), which is bound to the IQ domain of the Ca(V) carboxy tail. This modulator...

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Detalles Bibliográficos
Autores principales:	Sang, Lingjie, Vieira, Daiana C.O., Yue, David T., Ben-Johny, Manu, Dick, Ivy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054141/ https://www.ncbi.nlm.nih.gov/pubmed/33667546 http://dx.doi.org/10.1016/j.jbc.2021.100502

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