A novel partially open state of SHP2 points to a “multiple gear” regulation mechanism

The protein tyrosine phosphatase SHP2 mediates multiple signal transductions in various cellular pathways, controlled by a variety of upstream inputs. SHP2 dysregulation is causative of different types of cancers and developmental disorders, making it a promising drug target. However, how SHP2 is mo...

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Detalles Bibliográficos
Autores principales: Tao, Youqi, Xie, Jingfei, Zhong, Qinglu, Wang, Yongyao, Zhang, Shengnan, Luo, Feng, Wen, Fengcai, Xie, Jingjing, Zhao, Jiawei, Sun, Xiaoou, Long, Houfang, Ma, Junfeng, Zhang, Qian, Long, Jiangang, Fang, Xianyang, Lu, Ying, Li, Dan, Li, Ming, Zhu, Jidong, Sun, Bo, Li, Guohui, Diao, Jiajie, Liu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054191/
https://www.ncbi.nlm.nih.gov/pubmed/33722610
http://dx.doi.org/10.1016/j.jbc.2021.100538

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