J-domain proteins promote client relay from Hsp70 during tail-anchored membrane protein targeting

J-domain proteins (JDPs) play essential roles in Hsp70 function by assisting Hsp70 in client trapping and regulating the Hsp70 ATPase cycle. Here, we report that JDPs can further enhance the targeting competence of Hsp70-bound client proteins during tail-anchored protein (TA) biogenesis. In the guid...

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Detalles Bibliográficos
Autores principales: Cho, Hyunju, Shim, Woo Jun, Liu, Yumeng, Shan, Shu-ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054193/
https://www.ncbi.nlm.nih.gov/pubmed/33741343
http://dx.doi.org/10.1016/j.jbc.2021.100546

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