Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway

Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy to combat obesity. We identified that mesencephalic astrocyte–derived neurotrophic factor (Manf) is a feeding-induced hepatokine. Liver-specific Manf overexpression protected mice against...

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Detalles Bibliográficos
Autores principales: Wu, Tong, Liu, Qinhui, Li, Yanping, Li, Hong, Chen, Lei, Yang, Xuping, Tang, Qin, Pu, Shiyun, Kuang, Jiangying, Li, Rui, Huang, Ya, Zhang, Jinhang, Zhang, Zijing, Zhou, Jian, Huang, Cuiyuan, Zhang, Guorong, Zhao, Yingnan, Zou, Min, Jiang, Wei, Mo, Li, He, Jinhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054200/
https://www.ncbi.nlm.nih.gov/pubmed/33856409
http://dx.doi.org/10.1084/jem.20201203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054200/
https://www.ncbi.nlm.nih.gov/pubmed/33856409
http://dx.doi.org/10.1084/jem.20201203

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