Inhibition of acid sphingomyelinase increases regulatory T cells in humans

Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been shown to increase Foxp3(+) regulatory T-cell frequencies among CD4(+) T cells in mice. We now investigated whether pharmacological targeting of the acid sphingomyelinase, which catalyzes the cleavage of sphingomy...

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Detalles Bibliográficos
Autores principales: Wiese, Teresa, Dennstädt, Fabio, Hollmann, Claudia, Stonawski, Saskia, Wurst, Catherina, Fink, Julian, Gorte, Erika, Mandasari, Putri, Domschke, Katharina, Hommers, Leif, Vanhove, Bernard, Schumacher, Fabian, Kleuser, Burkhard, Seibel, Jürgen, Rohr, Jan, Buttmann, Mathias, Menke, Andreas, Schneider-Schaulies, Jürgen, Beyersdorf, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054263/
https://www.ncbi.nlm.nih.gov/pubmed/33898989
http://dx.doi.org/10.1093/braincomms/fcab020

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