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Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease

BACKGROUND: The clinical characteristics of Parkinson’s disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression. OBJECTIVE: To explore the features of excessive daytime sleepiness (...

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Autores principales: Liu, Ming, Luo, Ya-Jun, Gu, Han-Ying, Wang, Yi-Ming, Liu, Man-Hua, Li, Kai, Li, Jiao, Zhuang, Sheng, Shen, Yun, Jin, Hong, Chen, Jing, Mao, Cheng-Jie, Liu, Chun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054359/
https://www.ncbi.nlm.nih.gov/pubmed/33874914
http://dx.doi.org/10.1186/s12883-021-02192-x
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author Liu, Ming
Luo, Ya-Jun
Gu, Han-Ying
Wang, Yi-Ming
Liu, Man-Hua
Li, Kai
Li, Jiao
Zhuang, Sheng
Shen, Yun
Jin, Hong
Chen, Jing
Mao, Cheng-Jie
Liu, Chun-Feng
author_facet Liu, Ming
Luo, Ya-Jun
Gu, Han-Ying
Wang, Yi-Ming
Liu, Man-Hua
Li, Kai
Li, Jiao
Zhuang, Sheng
Shen, Yun
Jin, Hong
Chen, Jing
Mao, Cheng-Jie
Liu, Chun-Feng
author_sort Liu, Ming
collection PubMed
description BACKGROUND: The clinical characteristics of Parkinson’s disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression. OBJECTIVE: To explore the features of excessive daytime sleepiness (EDS) and night-time sleep quality in PD patients of different sexes and age at onset (AAO). METHODS: Demographic data and clinical characteristics of 586 PD patients were collected. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to investigate the daytime drowsiness and nocturnal sleep. Multivariate logistic regression analysis was used to explore the risk factors of EDS and poor night-time sleep quality. RESULTS: Sleep disorders were common in PD patients. EDS was more prominent in men than in women. There was no significant difference in ESS scores between late-onset PD (LOPD) and early-onset PD. LOPD patients had a higher probability of poor night-time sleep quality. Male sex, disease duration, and depression were risk factors for EDS. In all patients of both sexes and all AAO, depression was a risk factor for poor night-time sleep. CONCLUSION: More attention should be paid to sleep disorders of PD patients, especially male LOPD patients. Depression is a common risk factor for EDS and poor sleep quality in PD patients.
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spelling pubmed-80543592021-04-20 Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease Liu, Ming Luo, Ya-Jun Gu, Han-Ying Wang, Yi-Ming Liu, Man-Hua Li, Kai Li, Jiao Zhuang, Sheng Shen, Yun Jin, Hong Chen, Jing Mao, Cheng-Jie Liu, Chun-Feng BMC Neurol Research Article BACKGROUND: The clinical characteristics of Parkinson’s disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression. OBJECTIVE: To explore the features of excessive daytime sleepiness (EDS) and night-time sleep quality in PD patients of different sexes and age at onset (AAO). METHODS: Demographic data and clinical characteristics of 586 PD patients were collected. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to investigate the daytime drowsiness and nocturnal sleep. Multivariate logistic regression analysis was used to explore the risk factors of EDS and poor night-time sleep quality. RESULTS: Sleep disorders were common in PD patients. EDS was more prominent in men than in women. There was no significant difference in ESS scores between late-onset PD (LOPD) and early-onset PD. LOPD patients had a higher probability of poor night-time sleep quality. Male sex, disease duration, and depression were risk factors for EDS. In all patients of both sexes and all AAO, depression was a risk factor for poor night-time sleep. CONCLUSION: More attention should be paid to sleep disorders of PD patients, especially male LOPD patients. Depression is a common risk factor for EDS and poor sleep quality in PD patients. BioMed Central 2021-04-19 /pmc/articles/PMC8054359/ /pubmed/33874914 http://dx.doi.org/10.1186/s12883-021-02192-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Ming
Luo, Ya-Jun
Gu, Han-Ying
Wang, Yi-Ming
Liu, Man-Hua
Li, Kai
Li, Jiao
Zhuang, Sheng
Shen, Yun
Jin, Hong
Chen, Jing
Mao, Cheng-Jie
Liu, Chun-Feng
Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease
title Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease
title_full Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease
title_fullStr Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease
title_full_unstemmed Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease
title_short Sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with Parkinson’s disease
title_sort sex and onset-age-related features of excessive daytime sleepiness and night-time sleep in patients with parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054359/
https://www.ncbi.nlm.nih.gov/pubmed/33874914
http://dx.doi.org/10.1186/s12883-021-02192-x
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