Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

BACKGROUND: Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset. We have shown previously that monocytes from Huntington’s...

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Detalles Bibliográficos
Autores principales: O’Regan, Grace C., Farag, Sahar H., Casey, Caroline S., Wood-Kaczmar, Alison, Pocock, Jennifer M., Tabrizi, Sarah J., Andre, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054367/
https://www.ncbi.nlm.nih.gov/pubmed/33874957
http://dx.doi.org/10.1186/s12974-021-02147-6

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