Pirfenidone attenuates synovial fibrosis and postpones the progression of osteoarthritis by anti-fibrotic and anti-inflammatory properties in vivo and in vitro

BACKGROUND: Osteoarthritis (OA) is a disease of the entire joint involving synovial fibrosis and inflammation. Pathological changes to the synovium can accelerate the progression of OA. Pirfenidone (PFD) is a potent anti-fibrotic drug with additional anti-inflammatory properties. However, the influe...

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Detalles Bibliográficos
Autores principales: Wei, Qilu, Kong, Ning, Liu, Xiaohui, Tian, Run, Jiao, Ming, Li, Yiyang, Guan, Huanshuai, Wang, Kunzheng, Yang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054406/
https://www.ncbi.nlm.nih.gov/pubmed/33874948
http://dx.doi.org/10.1186/s12967-021-02823-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054406/
https://www.ncbi.nlm.nih.gov/pubmed/33874948
http://dx.doi.org/10.1186/s12967-021-02823-4

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