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Pirfenidone attenuates synovial fibrosis and postpones the progression of osteoarthritis by anti-fibrotic and anti-inflammatory properties in vivo and in vitro

BACKGROUND: Osteoarthritis (OA) is a disease of the entire joint involving synovial fibrosis and inflammation. Pathological changes to the synovium can accelerate the progression of OA. Pirfenidone (PFD) is a potent anti-fibrotic drug with additional anti-inflammatory properties. However, the influe...

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Detalles Bibliográficos
Autores principales:	Wei, Qilu, Kong, Ning, Liu, Xiaohui, Tian, Run, Jiao, Ming, Li, Yiyang, Guan, Huanshuai, Wang, Kunzheng, Yang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054406/ https://www.ncbi.nlm.nih.gov/pubmed/33874948 http://dx.doi.org/10.1186/s12967-021-02823-4

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