Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD

Mutation of C9ORF72 is the most prevalent defect in amyotrophic lateral sclerosis (ALS) and frontal temporal degeneration (FTD)(1). Together with hexanucleotide repeat expansion(2,3), haploinsufficiency of C9ORF72 contributes to neuronal dysfunction(4–6). We determined the structure of the C9orf72-S...

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Detalles Bibliográficos
Autores principales: Su, Ming-Yuan, Fromm, Simon A., Zoncu, Roberto, Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054479/
https://www.ncbi.nlm.nih.gov/pubmed/32848248
http://dx.doi.org/10.1038/s41586-020-2633-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054479/
https://www.ncbi.nlm.nih.gov/pubmed/32848248
http://dx.doi.org/10.1038/s41586-020-2633-x

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