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Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes
CONTEXT: The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score helps to diagnose necrotizing soft-tissue infection (NSTI). The LRINEC score has been reported to be associated with poor prognosis, although few studies have evaluated this association. AIMS: We aimed to describe the ch...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054806/ https://www.ncbi.nlm.nih.gov/pubmed/33911435 http://dx.doi.org/10.4103/JETS.JETS_17_20 |
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author | Fujinaga, Jun Kuriyama, Akira Ikegami, Tetsunori Onodera, Mutsuo |
author_facet | Fujinaga, Jun Kuriyama, Akira Ikegami, Tetsunori Onodera, Mutsuo |
author_sort | Fujinaga, Jun |
collection | PubMed |
description | CONTEXT: The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score helps to diagnose necrotizing soft-tissue infection (NSTI). The LRINEC score has been reported to be associated with poor prognosis, although few studies have evaluated this association. AIMS: We aimed to describe the characteristics of NSTI and assess whether the LRINEC score was associated with mortality and amputation. SETTINGS AND DESIGN: We conducted a retrospective observational study from January 2007 to May 2018, in a Japanese tertiary care hospital. SUBJECTS AND METHODS: Patients with NSTI were identified through our hospital database using the discharge diagnosis. We extracted data on patient characteristics, laboratory examinations, microbiological information, treatment, and in-hospital mortality. STATISTICAL ANALYSIS USED: We estimated the odds ratios (ORs) and associated 95% confidence intervals (CIs) for in-hospital mortality using logistic regression models. RESULTS: We identified 58 patients. The median LRINEC score was 8 (interquartile range [IQR]: 6–9). Forty-four patients (75.9%) scored 6 or more. The eight patients with amputations had a median score of 6 (IQR: 4.5–7.5) versus 8 (IQR: 7–9) for patients who underwent debridement (P = 0.091). Survivors and nonsurvivors had median scores of 8 (IQR: 6–9) and 6 (IQR: 5–8), respectively (P = 0.148). The OR for mortality in patients with liver cirrhosis was 10.5 (95% CI: 1.00–110.36; P = 0.050). CONCLUSIONS: There was no association between the LRINEC score and patients' outcomes: mortality and amputation. Further studies are warranted to evaluate the utility of the LRINEC score and factors associated with poor prognosis in patients with NSTI. |
format | Online Article Text |
id | pubmed-8054806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-80548062021-04-27 Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes Fujinaga, Jun Kuriyama, Akira Ikegami, Tetsunori Onodera, Mutsuo J Emerg Trauma Shock Original Article CONTEXT: The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score helps to diagnose necrotizing soft-tissue infection (NSTI). The LRINEC score has been reported to be associated with poor prognosis, although few studies have evaluated this association. AIMS: We aimed to describe the characteristics of NSTI and assess whether the LRINEC score was associated with mortality and amputation. SETTINGS AND DESIGN: We conducted a retrospective observational study from January 2007 to May 2018, in a Japanese tertiary care hospital. SUBJECTS AND METHODS: Patients with NSTI were identified through our hospital database using the discharge diagnosis. We extracted data on patient characteristics, laboratory examinations, microbiological information, treatment, and in-hospital mortality. STATISTICAL ANALYSIS USED: We estimated the odds ratios (ORs) and associated 95% confidence intervals (CIs) for in-hospital mortality using logistic regression models. RESULTS: We identified 58 patients. The median LRINEC score was 8 (interquartile range [IQR]: 6–9). Forty-four patients (75.9%) scored 6 or more. The eight patients with amputations had a median score of 6 (IQR: 4.5–7.5) versus 8 (IQR: 7–9) for patients who underwent debridement (P = 0.091). Survivors and nonsurvivors had median scores of 8 (IQR: 6–9) and 6 (IQR: 5–8), respectively (P = 0.148). The OR for mortality in patients with liver cirrhosis was 10.5 (95% CI: 1.00–110.36; P = 0.050). CONCLUSIONS: There was no association between the LRINEC score and patients' outcomes: mortality and amputation. Further studies are warranted to evaluate the utility of the LRINEC score and factors associated with poor prognosis in patients with NSTI. Wolters Kluwer - Medknow 2021 2021-03-23 /pmc/articles/PMC8054806/ /pubmed/33911435 http://dx.doi.org/10.4103/JETS.JETS_17_20 Text en Copyright: © 2021 Journal of Emergencies, Trauma, and Shock https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Fujinaga, Jun Kuriyama, Akira Ikegami, Tetsunori Onodera, Mutsuo Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes |
title | Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes |
title_full | Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes |
title_fullStr | Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes |
title_full_unstemmed | Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes |
title_short | Laboratory Risk Indicator for Necrotizing Fasciitis Score and Patient Outcomes |
title_sort | laboratory risk indicator for necrotizing fasciitis score and patient outcomes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054806/ https://www.ncbi.nlm.nih.gov/pubmed/33911435 http://dx.doi.org/10.4103/JETS.JETS_17_20 |
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