Cargando…

African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

OBJECTIVE: To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in groups of individuals who self-reported t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schindler, Suzanne E., Cruchaga, Carlos, Joseph, Amulya, McCue, Lena, Farias, Fabiana H.G., Wilkins, Consuelo H., Deming, Yuetiva, Henson, Rachel L., Mikesell, Robert J., Piccio, Laura, Llibre-Guerra, Jorge J., Moulder, Krista L., Fagan, Anne M., Ances, Beau M., Benzinger, Tammie L.S., Xiong, Chengjie, Holtzman, David M., Morris, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054965/ https://www.ncbi.nlm.nih.gov/pubmed/33884297 http://dx.doi.org/10.1212/NXG.0000000000000571

Ejemplares similares

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
por: Ewers, Michael, et al.
Publicado: (2020)

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
por: Cignarella, Francesca, et al.
Publicado: (2020)

Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status
por: Koenig, Lauren N., et al.
Publicado: (2021)

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
por: Suárez‐Calvet, Marc, et al.
Publicado: (2018)

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer’s disease
por: Sutphen, Courtney L., et al.
Publicado: (2018)

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
por: Suárez-Calvet, Marc, et al.
Publicado: (2019)

Falls: a marker of preclinical Alzheimer disease: a cohort study protocol
por: Bollinger, Rebecca M, et al.
Publicado: (2021)

Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage
por: Meeker, Karin L., et al.
Publicado: (2022)

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease
por: Wang, Qing, et al.
Publicado: (2019)

Using the A/T/N Framework to Examine Driving in Preclinical Alzheimer’s Disease
por: Roe, Catherine M., et al.
Publicado: (2018)

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
por: Kober, Daniel L, et al.
Publicado: (2016)

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
por: Ulrich, Jason D, et al.
Publicado: (2014)

Soluble TREM2: Innocent bystander or active player in neurological diseases?
por: Filipello, Fabia, et al.
Publicado: (2022)

Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease
por: Wang, Guoqiao, et al.
Publicado: (2018)

Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light
por: Schindler, Suzanne E., et al.
Publicado: (2022)

Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study
por: Morenas-Rodríguez, Estrella, et al.
Publicado: (2022)

Insights from new in vivo models of TREM2 variants
por: Jain, Nimansha, et al.
Publicado: (2023)

Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40
por: Wisch, Julie K., et al.
Publicado: (2023)

Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study
por: Millar, Peter R, et al.
Publicado: (2023)

New insights into the role of TREM2 in Alzheimer’s disease
por: Gratuze, Maud, et al.
Publicado: (2018)

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease
por: Brier, Matthew R., et al.
Publicado: (2016)

Comparing Tau PET Visual Interpretation with Tau PET Quantification, Cerebrospinal Fluid Biomarkers, and Longitudinal Clinical Assessment
por: Chen, Charles D., et al.
Publicado: (2023)

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease
por: Strain, Jeremy F., et al.
Publicado: (2022)

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
por: Del-Aguila, Jorge L., et al.
Publicado: (2019)

Flortaucipir (tau) PET in LGI1 antibody encephalitis
por: Day, Gregory S., et al.
Publicado: (2021)

CSF sTREM2: marking the tipping point between preclinical AD and dementia?
por: Schindler, Suzanne E, et al.
Publicado: (2016)

Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
por: Maxwell, Taylor J., et al.
Publicado: (2018)

Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology
por: Gordon, Brian A., et al.
Publicado: (2018)

The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia
por: Gordon, Brian A., et al.
Publicado: (2015)

Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
por: Deming, Yuetiva, et al.
Publicado: (2016)

Impaired and facilitated functional networks in temporal lobe epilepsy()
por: Maccotta, Luigi, et al.
Publicado: (2013)

Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease
por: Wang, Guoqiao, et al.
Publicado: (2019)

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading
por: Jain, Nimansha, et al.
Publicado: (2022)

Preclinical Alzheimer's disease and longitudinal driving decline
por: Roe, Catherine M., et al.
Publicado: (2016)

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease
por: Fernández, Maria V., et al.
Publicado: (2018)

TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model
por: Wang, Yaming, et al.
Publicado: (2015)

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
por: Deming, Yuetiva, et al.
Publicado: (2016)

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease
por: Llibre-Guerra, Jorge J., et al.
Publicado: (2019)

Relationships between big‐five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease
por: Aschenbrenner, Andrew J., et al.
Publicado: (2020)

Association of sex and APOE ε4 with brain tau deposition and atrophy in older adults with Alzheimer's disease
por: Yan, Shaozhen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0m0eb0bnrvp3s8v2vfo9gb8nun