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Progress toward improving outcomes in patients with cholangiocarcinoma
PURPOSE OF REVIEW: To provide an update on latest advances in treatment of cholangiocarcinoma. RECENT FINDINGS: Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier dia...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054970/ https://www.ncbi.nlm.nih.gov/pubmed/33883870 http://dx.doi.org/10.1007/s11938-021-00333-2 |
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author | Kawasaki, Hiroko Akazawa, Yuko Razumilava, Nataliya |
author_facet | Kawasaki, Hiroko Akazawa, Yuko Razumilava, Nataliya |
author_sort | Kawasaki, Hiroko |
collection | PubMed |
description | PURPOSE OF REVIEW: To provide an update on latest advances in treatment of cholangiocarcinoma. RECENT FINDINGS: Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier diagnosis and treatment option expansion to targeted therapy with FGFR inhibitors, and liver transplantation for early perihilar cholangiocarcinoma and early intrahepatic cholangiocarcinoma. IDH1/2 inhibition for intrahepatic cholangiocarcinoma is an emerging targeted therapy approach. Data supports benefits of adjuvant therapy for a subset of patients undergoing surgical resection. Approaches combining different treatment modalities such as chemotherapy, surgery, radiation therapy appear promising. SUMMARY: Earlier diagnosis and genetic characterization provided additional treatment options for patients with previously incurable cholangiocarcinoma. A precision medicine approach with a focus on actionable genetic alterations and combination of treatment modalities are actively being explored and will further improve outcomes in our patients with cholangiocarcinoma. |
format | Online Article Text |
id | pubmed-8054970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-80549702022-03-01 Progress toward improving outcomes in patients with cholangiocarcinoma Kawasaki, Hiroko Akazawa, Yuko Razumilava, Nataliya Curr Treat Options Gastroenterol Article PURPOSE OF REVIEW: To provide an update on latest advances in treatment of cholangiocarcinoma. RECENT FINDINGS: Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier diagnosis and treatment option expansion to targeted therapy with FGFR inhibitors, and liver transplantation for early perihilar cholangiocarcinoma and early intrahepatic cholangiocarcinoma. IDH1/2 inhibition for intrahepatic cholangiocarcinoma is an emerging targeted therapy approach. Data supports benefits of adjuvant therapy for a subset of patients undergoing surgical resection. Approaches combining different treatment modalities such as chemotherapy, surgery, radiation therapy appear promising. SUMMARY: Earlier diagnosis and genetic characterization provided additional treatment options for patients with previously incurable cholangiocarcinoma. A precision medicine approach with a focus on actionable genetic alterations and combination of treatment modalities are actively being explored and will further improve outcomes in our patients with cholangiocarcinoma. 2021-01-30 2021-03 /pmc/articles/PMC8054970/ /pubmed/33883870 http://dx.doi.org/10.1007/s11938-021-00333-2 Text en https://creativecommons.org/licenses/by/4.0/Terms of use and reuse: academic research for non-commercial purposes, see here for full terms. http://www.springer.com/gb/open-access/authors-rights/aam-terms-v1 |
spellingShingle | Article Kawasaki, Hiroko Akazawa, Yuko Razumilava, Nataliya Progress toward improving outcomes in patients with cholangiocarcinoma |
title | Progress toward improving outcomes in patients with cholangiocarcinoma |
title_full | Progress toward improving outcomes in patients with cholangiocarcinoma |
title_fullStr | Progress toward improving outcomes in patients with cholangiocarcinoma |
title_full_unstemmed | Progress toward improving outcomes in patients with cholangiocarcinoma |
title_short | Progress toward improving outcomes in patients with cholangiocarcinoma |
title_sort | progress toward improving outcomes in patients with cholangiocarcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054970/ https://www.ncbi.nlm.nih.gov/pubmed/33883870 http://dx.doi.org/10.1007/s11938-021-00333-2 |
work_keys_str_mv | AT kawasakihiroko progresstowardimprovingoutcomesinpatientswithcholangiocarcinoma AT akazawayuko progresstowardimprovingoutcomesinpatientswithcholangiocarcinoma AT razumilavanataliya progresstowardimprovingoutcomesinpatientswithcholangiocarcinoma |