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Progress toward improving outcomes in patients with cholangiocarcinoma

PURPOSE OF REVIEW: To provide an update on latest advances in treatment of cholangiocarcinoma. RECENT FINDINGS: Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier dia...

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Autores principales: Kawasaki, Hiroko, Akazawa, Yuko, Razumilava, Nataliya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054970/
https://www.ncbi.nlm.nih.gov/pubmed/33883870
http://dx.doi.org/10.1007/s11938-021-00333-2
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author Kawasaki, Hiroko
Akazawa, Yuko
Razumilava, Nataliya
author_facet Kawasaki, Hiroko
Akazawa, Yuko
Razumilava, Nataliya
author_sort Kawasaki, Hiroko
collection PubMed
description PURPOSE OF REVIEW: To provide an update on latest advances in treatment of cholangiocarcinoma. RECENT FINDINGS: Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier diagnosis and treatment option expansion to targeted therapy with FGFR inhibitors, and liver transplantation for early perihilar cholangiocarcinoma and early intrahepatic cholangiocarcinoma. IDH1/2 inhibition for intrahepatic cholangiocarcinoma is an emerging targeted therapy approach. Data supports benefits of adjuvant therapy for a subset of patients undergoing surgical resection. Approaches combining different treatment modalities such as chemotherapy, surgery, radiation therapy appear promising. SUMMARY: Earlier diagnosis and genetic characterization provided additional treatment options for patients with previously incurable cholangiocarcinoma. A precision medicine approach with a focus on actionable genetic alterations and combination of treatment modalities are actively being explored and will further improve outcomes in our patients with cholangiocarcinoma.
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spelling pubmed-80549702022-03-01 Progress toward improving outcomes in patients with cholangiocarcinoma Kawasaki, Hiroko Akazawa, Yuko Razumilava, Nataliya Curr Treat Options Gastroenterol Article PURPOSE OF REVIEW: To provide an update on latest advances in treatment of cholangiocarcinoma. RECENT FINDINGS: Incidence of cholangiocarcinoma has been increasing over the past decade. A better understanding of the genetic landscape of cholangiocarcinoma and its risk factors resulted in earlier diagnosis and treatment option expansion to targeted therapy with FGFR inhibitors, and liver transplantation for early perihilar cholangiocarcinoma and early intrahepatic cholangiocarcinoma. IDH1/2 inhibition for intrahepatic cholangiocarcinoma is an emerging targeted therapy approach. Data supports benefits of adjuvant therapy for a subset of patients undergoing surgical resection. Approaches combining different treatment modalities such as chemotherapy, surgery, radiation therapy appear promising. SUMMARY: Earlier diagnosis and genetic characterization provided additional treatment options for patients with previously incurable cholangiocarcinoma. A precision medicine approach with a focus on actionable genetic alterations and combination of treatment modalities are actively being explored and will further improve outcomes in our patients with cholangiocarcinoma. 2021-01-30 2021-03 /pmc/articles/PMC8054970/ /pubmed/33883870 http://dx.doi.org/10.1007/s11938-021-00333-2 Text en https://creativecommons.org/licenses/by/4.0/Terms of use and reuse: academic research for non-commercial purposes, see here for full terms. http://www.springer.com/gb/open-access/authors-rights/aam-terms-v1
spellingShingle Article
Kawasaki, Hiroko
Akazawa, Yuko
Razumilava, Nataliya
Progress toward improving outcomes in patients with cholangiocarcinoma
title Progress toward improving outcomes in patients with cholangiocarcinoma
title_full Progress toward improving outcomes in patients with cholangiocarcinoma
title_fullStr Progress toward improving outcomes in patients with cholangiocarcinoma
title_full_unstemmed Progress toward improving outcomes in patients with cholangiocarcinoma
title_short Progress toward improving outcomes in patients with cholangiocarcinoma
title_sort progress toward improving outcomes in patients with cholangiocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054970/
https://www.ncbi.nlm.nih.gov/pubmed/33883870
http://dx.doi.org/10.1007/s11938-021-00333-2
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