Cargando…

ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing

ELAV/Hu factors are conserved RNA binding proteins (RBPs) that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago. Nevertheless, little was known about its impacts on the transcriptome, and potential functi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seungjae, Wei, Lu, Zhang, Binglong, Goering, Raeann, Majumdar, Sonali, Wen, Jiayu, Taliaferro, J. Matthew, Lai, Eric C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055025/ https://www.ncbi.nlm.nih.gov/pubmed/33826609 http://dx.doi.org/10.1371/journal.pgen.1009439

Ejemplares similares

Regulation of the Alternative Neural Transcriptome by ELAV/Hu RNA Binding Proteins
por: Wei, Lu, et al.
Publicado: (2022)

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation
por: Mansfield, Kyle D., et al.
Publicado: (2012)

LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival
por: Goering, Raeann, et al.
Publicado: (2021)

The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization
por: Arora, Ankita, et al.
Publicado: (2022)

In Vivo Interaction of the Hepatitis Delta Virus Small Antigen with the ELAV-Like Protein HuR
por: Casaca, Ana, et al.
Publicado: (2011)

Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory
por: Ustaoglu, Pinar, et al.
Publicado: (2021)

Posttranscriptional Regulation of Gene Expression Participates in the Myelin Restoration in Mouse Models of Multiple Sclerosis: Antisense Modulation of HuR and HuD ELAV RNA Binding Protein
por: Borgonetti, Vittoria, et al.
Publicado: (2023)

A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation
por: Carrasco, Judit, et al.
Publicado: (2022)

The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth
por: Alizzi, Rebecca A., et al.
Publicado: (2020)

RNA localization mechanisms transcend cell morphology
por: Goering, Raeann, et al.
Publicado: (2023)

Unlike Drosophila elav, the C. elegans elav orthologue exc-7 is not panneuronally expressed
por: Pham, Kenneth, et al.
Publicado: (2019)

The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex
por: Sena, Rebecca M., et al.
Publicado: (2021)

Regulation of alternative splicing and polyadenylation in neurons
por: Lee, Seungjae, et al.
Publicado: (2023)

Alternative splicing of the neurofibromatosis type 1 pre-mRNA is regulated by the muscleblind-like proteins and the CUG-BP and ELAV-like factors
por: Fleming, Victoria A, et al.
Publicado: (2012)

Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells
por: Leandersson, Karin, et al.
Publicado: (2006)

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes
por: Doller, Anke, et al.
Publicado: (2013)

The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation
por: Meng, Zheng, et al.
Publicado: (2005)

Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1
por: Amadio, Marialaura, et al.
Publicado: (2015)

Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L
por: Winkler, C, et al.
Publicado: (2014)

Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth
por: Zhang, Zhiping, et al.
Publicado: (2019)

Rapid functional diversification in the structurally conserved ELAV family of neuronal RNA binding proteins
por: Samson, Marie-Laure
Publicado: (2008)

Shared RNA-binding sites for interacting members of the Drosophila ELAV family of neuronal proteins
por: Borgeson, Claudia D., et al.
Publicado: (2005)

Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model
por: Amadio, M., et al.
Publicado: (2012)

Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq
por: Engel, Krysta L, et al.
Publicado: (2021)

Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain
por: Scheckel, Claudia, et al.
Publicado: (2016)

Diverse cell-specific patterns of alternative polyadenylation in Drosophila
por: Lee, Seungjae, et al.
Publicado: (2022)

The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system
por: Rogulja-Ortmann, Ana, et al.
Publicado: (2014)

Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference
por: Castro Alvarez, Javier J., et al.
Publicado: (2021)

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
por: Goering, Raeann, et al.
Publicado: (2020)

Alternative splicing complexity contributes to genetic improvement of drought resistance in the rice maintainer HuHan2B
por: Wei, Haibin, et al.
Publicado: (2017)

The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization
por: Toba, Gakuta, et al.
Publicado: (2008)

Melav2, an elav-like gene, is essential for spermatid differentiation in the flatworm Macrostomum lignano
por: Sekii, Kiyono, et al.
Publicado: (2009)

Alternative Splicing Programs in Prostate Cancer
por: Sette, Claudio
Publicado: (2013)

All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing
por: Hinman, Melissa N., et al.
Publicado: (2013)

HuR and TIA1/TIAL1 Are Involved in Regulation of Alternative Splicing of SIRT1 Pre-mRNA
por: Zhao, Wenhui, et al.
Publicado: (2014)

Syntrophin binds to an alternatively spliced exon of dystrophin
Publicado: (1995)

An Alternative Splicing Program for Mouse Craniofacial Development
por: Hooper, Joan E., et al.
Publicado: (2020)

The fitness cost of mis-splicing is the main determinant of alternative splicing patterns
por: Saudemont, Baptiste, et al.
Publicado: (2017)

QTL mapping of seedling tolerance to exposure to low temperature in the maize IBM RIL population
por: Goering, Raeann, et al.
Publicado: (2021)

Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme
por: Huang, Runzhi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hs3trka014upc5pk1mt33lj12b