Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define...

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Detalles Bibliográficos
Autores principales: Chen, Luke Y.C., Biggs, Catherine M., Jamal, Shahin, Stukas, Sophie, Wellington, Cheryl L., Sekhon, Mypinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055165/
https://www.ncbi.nlm.nih.gov/pubmed/33899032
http://dx.doi.org/10.1016/j.xcrm.2021.100269
Descripción
Sumario:Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.

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