Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define...

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Autores principales: Chen, Luke Y.C., Biggs, Catherine M., Jamal, Shahin, Stukas, Sophie, Wellington, Cheryl L., Sekhon, Mypinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055165/
https://www.ncbi.nlm.nih.gov/pubmed/33899032
http://dx.doi.org/10.1016/j.xcrm.2021.100269
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author Chen, Luke Y.C.
Biggs, Catherine M.
Jamal, Shahin
Stukas, Sophie
Wellington, Cheryl L.
Sekhon, Mypinder S.
author_facet Chen, Luke Y.C.
Biggs, Catherine M.
Jamal, Shahin
Stukas, Sophie
Wellington, Cheryl L.
Sekhon, Mypinder S.
author_sort Chen, Luke Y.C.
collection PubMed
description Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.
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spelling pubmed-80551652021-04-20 Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome Chen, Luke Y.C. Biggs, Catherine M. Jamal, Shahin Stukas, Sophie Wellington, Cheryl L. Sekhon, Mypinder S. Cell Rep Med Commentary Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome. Elsevier 2021-04-19 /pmc/articles/PMC8055165/ /pubmed/33899032 http://dx.doi.org/10.1016/j.xcrm.2021.100269 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Chen, Luke Y.C.
Biggs, Catherine M.
Jamal, Shahin
Stukas, Sophie
Wellington, Cheryl L.
Sekhon, Mypinder S.
Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
title Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
title_full Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
title_fullStr Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
title_full_unstemmed Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
title_short Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
title_sort soluble interleukin-6 receptor in the covid-19 cytokine storm syndrome
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055165/
https://www.ncbi.nlm.nih.gov/pubmed/33899032
http://dx.doi.org/10.1016/j.xcrm.2021.100269
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