VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy

Duchenne muscular dystrophy is characterized by structural degeneration of muscle, which is exacerbated by localized functional ischemia due to loss of nitric oxide synthase-induced vasodilation. Treatment strategies aimed at increasing vascular perfusion have been proposed. Toward this end, we have...

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Detalles Bibliográficos
Autores principales: Bosco, Jennifer, Zhou, Zhiwei, Gabriëls, Sofie, Verma, Mayank, Liu, Nan, Miller, Brian K., Gu, Sheng, Lundberg, Dianna M., Huang, Yan, Brown, Eilish, Josiah, Serene, Meiyappan, Muthuraman, Traylor, Matthew J., Chen, Nancy, Asakura, Atsushi, De Jonge, Natalie, Blanchetot, Christophe, de Haard, Hans, Duffy, Heather S., Keefe, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055526/
https://www.ncbi.nlm.nih.gov/pubmed/33898634
http://dx.doi.org/10.1016/j.omtm.2021.03.013

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