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Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot

Phosphaturic mesenchymal tumors are the main cause of tumor-induced osteomalacia, a distinctive paraneoplastic syndrome mediated by overproduction of fibroblast growth factor 23, that leads to renal phosphate wasting and hypophosphatemia. Diagnosis of this mesenchymal tumors is difficult and usually...

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Autores principales: Correia, Joana, Machado, Marino, Gonçalves, Rui, Jonge, Frederik, Micaelo, Manuela, Pedrosa, Carlos, Portela, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055529/
https://www.ncbi.nlm.nih.gov/pubmed/33897929
http://dx.doi.org/10.1016/j.radcr.2021.03.015
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author Correia, Joana
Machado, Marino
Gonçalves, Rui
Jonge, Frederik
Micaelo, Manuela
Pedrosa, Carlos
Portela, José
author_facet Correia, Joana
Machado, Marino
Gonçalves, Rui
Jonge, Frederik
Micaelo, Manuela
Pedrosa, Carlos
Portela, José
author_sort Correia, Joana
collection PubMed
description Phosphaturic mesenchymal tumors are the main cause of tumor-induced osteomalacia, a distinctive paraneoplastic syndrome mediated by overproduction of fibroblast growth factor 23, that leads to renal phosphate wasting and hypophosphatemia. Diagnosis of this mesenchymal tumors is difficult and usually delayed for several years. We present the case of a 70-years-old-male with generalized bone pain, multiple pathological fractures and persistent hypophosphatemia, diagnosed with tumor-induced osteomalacia after 4 years of the onset of symptoms. The tumor was localized in the forefoot using Gallium 68-DOTANOC positron emission tomography-computed tomography and successfully surgically treated. This case report highlights the importance of recognizing these rare tumors, as early diagnosis can prevent long-term morbidity.
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spelling pubmed-80555292021-04-22 Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot Correia, Joana Machado, Marino Gonçalves, Rui Jonge, Frederik Micaelo, Manuela Pedrosa, Carlos Portela, José Radiol Case Rep Case Report Phosphaturic mesenchymal tumors are the main cause of tumor-induced osteomalacia, a distinctive paraneoplastic syndrome mediated by overproduction of fibroblast growth factor 23, that leads to renal phosphate wasting and hypophosphatemia. Diagnosis of this mesenchymal tumors is difficult and usually delayed for several years. We present the case of a 70-years-old-male with generalized bone pain, multiple pathological fractures and persistent hypophosphatemia, diagnosed with tumor-induced osteomalacia after 4 years of the onset of symptoms. The tumor was localized in the forefoot using Gallium 68-DOTANOC positron emission tomography-computed tomography and successfully surgically treated. This case report highlights the importance of recognizing these rare tumors, as early diagnosis can prevent long-term morbidity. Elsevier 2021-04-09 /pmc/articles/PMC8055529/ /pubmed/33897929 http://dx.doi.org/10.1016/j.radcr.2021.03.015 Text en © 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Correia, Joana
Machado, Marino
Gonçalves, Rui
Jonge, Frederik
Micaelo, Manuela
Pedrosa, Carlos
Portela, José
Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
title Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
title_full Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
title_fullStr Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
title_full_unstemmed Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
title_short Delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
title_sort delayed diagnosis of occult phosphaturic mesenchymal tumor in the foot
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055529/
https://www.ncbi.nlm.nih.gov/pubmed/33897929
http://dx.doi.org/10.1016/j.radcr.2021.03.015
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