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Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities

In bacterial communities, cells often communicate by the release and detection of small diffusible molecules, a process termed quorum-sensing. Signal molecules are thought to broadly diffuse in space; however, they often regulate traits such as conjugative transfer that strictly depend on the local...

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Autores principales: van Gestel, Jordi, Bareia, Tasneem, Tenennbaum, Bar, Dal Co, Alma, Guler, Polina, Aframian, Nitzan, Puyesky, Shani, Grinberg, Ilana, D’Souza, Glen G., Erez, Zohar, Ackermann, Martin, Eldar, Avigdor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055654/
https://www.ncbi.nlm.nih.gov/pubmed/33875666
http://dx.doi.org/10.1038/s41467-021-22649-4
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author van Gestel, Jordi
Bareia, Tasneem
Tenennbaum, Bar
Dal Co, Alma
Guler, Polina
Aframian, Nitzan
Puyesky, Shani
Grinberg, Ilana
D’Souza, Glen G.
Erez, Zohar
Ackermann, Martin
Eldar, Avigdor
author_facet van Gestel, Jordi
Bareia, Tasneem
Tenennbaum, Bar
Dal Co, Alma
Guler, Polina
Aframian, Nitzan
Puyesky, Shani
Grinberg, Ilana
D’Souza, Glen G.
Erez, Zohar
Ackermann, Martin
Eldar, Avigdor
author_sort van Gestel, Jordi
collection PubMed
description In bacterial communities, cells often communicate by the release and detection of small diffusible molecules, a process termed quorum-sensing. Signal molecules are thought to broadly diffuse in space; however, they often regulate traits such as conjugative transfer that strictly depend on the local community composition. This raises the question how nearby cells within the community can be detected. Here, we compare the range of communication of different quorum-sensing systems. While some systems support long-range communication, we show that others support a form of highly localized communication. In these systems, signal molecules propagate no more than a few microns away from signaling cells, due to the irreversible uptake of the signal molecules from the environment. This enables cells to accurately detect micron scale changes in the community composition. Several mobile genetic elements, including conjugative elements and phages, employ short-range communication to assess the fraction of susceptible host cells in their vicinity and adaptively trigger horizontal gene transfer in response. Our results underscore the complex spatial biology of bacteria, which can communicate and interact at widely different spatial scales.
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spelling pubmed-80556542021-05-11 Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities van Gestel, Jordi Bareia, Tasneem Tenennbaum, Bar Dal Co, Alma Guler, Polina Aframian, Nitzan Puyesky, Shani Grinberg, Ilana D’Souza, Glen G. Erez, Zohar Ackermann, Martin Eldar, Avigdor Nat Commun Article In bacterial communities, cells often communicate by the release and detection of small diffusible molecules, a process termed quorum-sensing. Signal molecules are thought to broadly diffuse in space; however, they often regulate traits such as conjugative transfer that strictly depend on the local community composition. This raises the question how nearby cells within the community can be detected. Here, we compare the range of communication of different quorum-sensing systems. While some systems support long-range communication, we show that others support a form of highly localized communication. In these systems, signal molecules propagate no more than a few microns away from signaling cells, due to the irreversible uptake of the signal molecules from the environment. This enables cells to accurately detect micron scale changes in the community composition. Several mobile genetic elements, including conjugative elements and phages, employ short-range communication to assess the fraction of susceptible host cells in their vicinity and adaptively trigger horizontal gene transfer in response. Our results underscore the complex spatial biology of bacteria, which can communicate and interact at widely different spatial scales. Nature Publishing Group UK 2021-04-19 /pmc/articles/PMC8055654/ /pubmed/33875666 http://dx.doi.org/10.1038/s41467-021-22649-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
van Gestel, Jordi
Bareia, Tasneem
Tenennbaum, Bar
Dal Co, Alma
Guler, Polina
Aframian, Nitzan
Puyesky, Shani
Grinberg, Ilana
D’Souza, Glen G.
Erez, Zohar
Ackermann, Martin
Eldar, Avigdor
Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
title Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
title_full Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
title_fullStr Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
title_full_unstemmed Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
title_short Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
title_sort short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055654/
https://www.ncbi.nlm.nih.gov/pubmed/33875666
http://dx.doi.org/10.1038/s41467-021-22649-4
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