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Atrial fibrillation and left atrial size and function: a Mendelian randomization study

Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and LA size and function. In the UK Biobank, all individuals with contoured cardi...

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Autores principales: van de Vegte, Yordi J., Siland, Joylene E., Rienstra, Michiel, van der Harst, Pim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055882/
https://www.ncbi.nlm.nih.gov/pubmed/33875748
http://dx.doi.org/10.1038/s41598-021-87859-8
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author van de Vegte, Yordi J.
Siland, Joylene E.
Rienstra, Michiel
van der Harst, Pim
author_facet van de Vegte, Yordi J.
Siland, Joylene E.
Rienstra, Michiel
van der Harst, Pim
author_sort van de Vegte, Yordi J.
collection PubMed
description Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and LA size and function. In the UK Biobank, all individuals with contoured cardiovascular magnetic resonance data were selected. LA maximal volume (LA max), LA minimal volume (LA min), LA stroke volume and LA ejection fraction were measured and indexed to body surface area (BSA). Two-sample Mendelian randomization analyses were performed using 84 of the known genetic variants associated with AF to assess the association with all LA size and function in individuals without prevalent AF. A total of 4274 individuals (mean age 62.0 ± 7.5 years, 53.2% women) were included. Mendelian randomization analyses estimated a causal effect between genetically determined AF and BSA-indexed LA max, LA min, and LA ejection fraction, but not between AF and LA stroke volume. Leave-one-out analyses showed that the causal associations were attenuated after exclusion of rs67249485, located near PITX2 gene. Our results suggest that AF causally increases LA size and decreases LA ejection fraction. The AF risk allele of rs67249485, located near the PITX2 gene, contributes strongly to these associations.
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spelling pubmed-80558822021-04-22 Atrial fibrillation and left atrial size and function: a Mendelian randomization study van de Vegte, Yordi J. Siland, Joylene E. Rienstra, Michiel van der Harst, Pim Sci Rep Article Atrial fibrillation (AF) patients have enlarged left atria (LA), but prior studies suggested enlarged atria as both cause and consequence of AF. The aim of this study is to investigate the causal association between AF and LA size and function. In the UK Biobank, all individuals with contoured cardiovascular magnetic resonance data were selected. LA maximal volume (LA max), LA minimal volume (LA min), LA stroke volume and LA ejection fraction were measured and indexed to body surface area (BSA). Two-sample Mendelian randomization analyses were performed using 84 of the known genetic variants associated with AF to assess the association with all LA size and function in individuals without prevalent AF. A total of 4274 individuals (mean age 62.0 ± 7.5 years, 53.2% women) were included. Mendelian randomization analyses estimated a causal effect between genetically determined AF and BSA-indexed LA max, LA min, and LA ejection fraction, but not between AF and LA stroke volume. Leave-one-out analyses showed that the causal associations were attenuated after exclusion of rs67249485, located near PITX2 gene. Our results suggest that AF causally increases LA size and decreases LA ejection fraction. The AF risk allele of rs67249485, located near the PITX2 gene, contributes strongly to these associations. Nature Publishing Group UK 2021-04-19 /pmc/articles/PMC8055882/ /pubmed/33875748 http://dx.doi.org/10.1038/s41598-021-87859-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
van de Vegte, Yordi J.
Siland, Joylene E.
Rienstra, Michiel
van der Harst, Pim
Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_full Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_fullStr Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_full_unstemmed Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_short Atrial fibrillation and left atrial size and function: a Mendelian randomization study
title_sort atrial fibrillation and left atrial size and function: a mendelian randomization study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055882/
https://www.ncbi.nlm.nih.gov/pubmed/33875748
http://dx.doi.org/10.1038/s41598-021-87859-8
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