Adapting CRISPR/Cas9 System for Targeting Mitochondrial Genome

Gene editing of the mitochondrial genome using the CRISPR-Cas9 system is highly challenging mainly due to sub-efficient delivery of guide RNA and Cas9 enzyme complexes into the mitochondria. In this study, we were able to perform gene editing in the mitochondrial DNA by appending an NADH-ubiquinone...

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Detalles Bibliográficos
Autores principales: Hussain, Syed-Rehan A., Yalvac, Mehmet E., Khoo, Benedict, Eckardt, Sigrid, McLaughlin, K. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055930/
https://www.ncbi.nlm.nih.gov/pubmed/33889176
http://dx.doi.org/10.3389/fgene.2021.627050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055930/
https://www.ncbi.nlm.nih.gov/pubmed/33889176
http://dx.doi.org/10.3389/fgene.2021.627050

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