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Adapting CRISPR/Cas9 System for Targeting Mitochondrial Genome

Gene editing of the mitochondrial genome using the CRISPR-Cas9 system is highly challenging mainly due to sub-efficient delivery of guide RNA and Cas9 enzyme complexes into the mitochondria. In this study, we were able to perform gene editing in the mitochondrial DNA by appending an NADH-ubiquinone...

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Detalles Bibliográficos
Autores principales:	Hussain, Syed-Rehan A., Yalvac, Mehmet E., Khoo, Benedict, Eckardt, Sigrid, McLaughlin, K. John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055930/ https://www.ncbi.nlm.nih.gov/pubmed/33889176 http://dx.doi.org/10.3389/fgene.2021.627050

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