Cargando…
Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independ...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055991/ https://www.ncbi.nlm.nih.gov/pubmed/33875671 http://dx.doi.org/10.1038/s41598-021-86179-1 |
_version_ | 1783680558142849024 |
---|---|
author | Ko, Hsin-Kuo Cheng, Shih-Lung Lin, Ching-Hsiung Lin, Sheng-Hao Hsiao, Yi-Han Su, Kang-Cheng Yu, Chong-Jen Wang, Hao-Chien Sheu, Chau-Chyun Chiu, Kuo-Chin Perng, Diahn-Warng |
author_facet | Ko, Hsin-Kuo Cheng, Shih-Lung Lin, Ching-Hsiung Lin, Sheng-Hao Hsiao, Yi-Han Su, Kang-Cheng Yu, Chong-Jen Wang, Hao-Chien Sheu, Chau-Chyun Chiu, Kuo-Chin Perng, Diahn-Warng |
author_sort | Ko, Hsin-Kuo |
collection | PubMed |
description | Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. In this multi-center prospective observational study, 132 patients with severe asthma were enrolled and divided into exacerbation (n = 52) and non-exacerbation (n = 80) groups on the basis of exacerbation rate after a 1-year follow-up period. We found that previous history of severe-to-serious exacerbation, baseline blood eosinophil counts (≥ 291cells/μL), and serum tryptase (≤ 1448 pg/mL) and thrymic stromal lymphopoietin (TSLP) levels (≥ 25 pg/mL) independently predicted the future development of exacerbation with adjusted odds ratios (AOR) of 3.27, 6.04, 2.53 and 8.67, respectively. Notably, the patients with high blood eosinophil counts and low tryptase levels were likely to have more exacerbations than those with low blood eosinophil counts and high tryptase levels (AOR 16.9). TSLP potentially played the pathogenic role across different asthma phenotypes. TSLP and tryptase levels may be implicated in steroid resistance and responsiveness in the asthma inflammatory process. High blood eosinophil counts and low serum tryptase levels predict a high probability of future asthma exacerbation. |
format | Online Article Text |
id | pubmed-8055991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80559912021-04-22 Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma Ko, Hsin-Kuo Cheng, Shih-Lung Lin, Ching-Hsiung Lin, Sheng-Hao Hsiao, Yi-Han Su, Kang-Cheng Yu, Chong-Jen Wang, Hao-Chien Sheu, Chau-Chyun Chiu, Kuo-Chin Perng, Diahn-Warng Sci Rep Article Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. In this multi-center prospective observational study, 132 patients with severe asthma were enrolled and divided into exacerbation (n = 52) and non-exacerbation (n = 80) groups on the basis of exacerbation rate after a 1-year follow-up period. We found that previous history of severe-to-serious exacerbation, baseline blood eosinophil counts (≥ 291cells/μL), and serum tryptase (≤ 1448 pg/mL) and thrymic stromal lymphopoietin (TSLP) levels (≥ 25 pg/mL) independently predicted the future development of exacerbation with adjusted odds ratios (AOR) of 3.27, 6.04, 2.53 and 8.67, respectively. Notably, the patients with high blood eosinophil counts and low tryptase levels were likely to have more exacerbations than those with low blood eosinophil counts and high tryptase levels (AOR 16.9). TSLP potentially played the pathogenic role across different asthma phenotypes. TSLP and tryptase levels may be implicated in steroid resistance and responsiveness in the asthma inflammatory process. High blood eosinophil counts and low serum tryptase levels predict a high probability of future asthma exacerbation. Nature Publishing Group UK 2021-04-19 /pmc/articles/PMC8055991/ /pubmed/33875671 http://dx.doi.org/10.1038/s41598-021-86179-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ko, Hsin-Kuo Cheng, Shih-Lung Lin, Ching-Hsiung Lin, Sheng-Hao Hsiao, Yi-Han Su, Kang-Cheng Yu, Chong-Jen Wang, Hao-Chien Sheu, Chau-Chyun Chiu, Kuo-Chin Perng, Diahn-Warng Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
title | Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
title_full | Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
title_fullStr | Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
title_full_unstemmed | Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
title_short | Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
title_sort | blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055991/ https://www.ncbi.nlm.nih.gov/pubmed/33875671 http://dx.doi.org/10.1038/s41598-021-86179-1 |
work_keys_str_mv | AT kohsinkuo bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT chengshihlung bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT linchinghsiung bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT linshenghao bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT hsiaoyihan bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT sukangcheng bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT yuchongjen bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT wanghaochien bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT sheuchauchyun bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT chiukuochin bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma AT perngdiahnwarng bloodtryptaseandthymicstromallymphopoietinlevelspredicttheriskofexacerbationinsevereasthma |