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Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates

Many works have reported that protein folding rates are influenced by the characteristics of amino acid sequences and protein structures. However, few reports on the problem of whether the corresponding mRNA sequences are related to the protein folding rates can be found. An mRNA sequence is regarde...

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Autores principales: Li, Ruifang, Li, Hong, Feng, Xue, Zhao, Ruifeng, Cheng, Yongxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056030/
https://www.ncbi.nlm.nih.gov/pubmed/33889178
http://dx.doi.org/10.3389/fgene.2021.635250
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author Li, Ruifang
Li, Hong
Feng, Xue
Zhao, Ruifeng
Cheng, Yongxia
author_facet Li, Ruifang
Li, Hong
Feng, Xue
Zhao, Ruifeng
Cheng, Yongxia
author_sort Li, Ruifang
collection PubMed
description Many works have reported that protein folding rates are influenced by the characteristics of amino acid sequences and protein structures. However, few reports on the problem of whether the corresponding mRNA sequences are related to the protein folding rates can be found. An mRNA sequence is regarded as a kind of genetic language, and its vocabulary and phraseology must provide influential information regarding the protein folding rate. In the present work, linear regressions on the parameters of the vocabulary and phraseology of mRNA sequences and the corresponding protein folding rates were analyzed. The results indicated that D(2) (the adjacent base-related information redundancy) values and the GC content values of the corresponding mRNA sequences exhibit significant negative relations with the protein folding rates, but D(1) (the single base information redundancy) values exhibit significant positive relations with the protein folding rates. In addition, the results show that the relationships between the parameters of the genetic language and the corresponding protein folding rates are obviously different for different protein groups. Some useful parameters that are related to protein folding rates were found. The results indicate that when predicting protein folding rates, the information from protein structures and their amino acid sequences is insufficient, and some information for regulating the protein folding rates must be derived from the mRNA sequences.
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spelling pubmed-80560302021-04-21 Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates Li, Ruifang Li, Hong Feng, Xue Zhao, Ruifeng Cheng, Yongxia Front Genet Genetics Many works have reported that protein folding rates are influenced by the characteristics of amino acid sequences and protein structures. However, few reports on the problem of whether the corresponding mRNA sequences are related to the protein folding rates can be found. An mRNA sequence is regarded as a kind of genetic language, and its vocabulary and phraseology must provide influential information regarding the protein folding rate. In the present work, linear regressions on the parameters of the vocabulary and phraseology of mRNA sequences and the corresponding protein folding rates were analyzed. The results indicated that D(2) (the adjacent base-related information redundancy) values and the GC content values of the corresponding mRNA sequences exhibit significant negative relations with the protein folding rates, but D(1) (the single base information redundancy) values exhibit significant positive relations with the protein folding rates. In addition, the results show that the relationships between the parameters of the genetic language and the corresponding protein folding rates are obviously different for different protein groups. Some useful parameters that are related to protein folding rates were found. The results indicate that when predicting protein folding rates, the information from protein structures and their amino acid sequences is insufficient, and some information for regulating the protein folding rates must be derived from the mRNA sequences. Frontiers Media S.A. 2021-04-06 /pmc/articles/PMC8056030/ /pubmed/33889178 http://dx.doi.org/10.3389/fgene.2021.635250 Text en Copyright © 2021 Li, Li, Feng, Zhao and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Ruifang
Li, Hong
Feng, Xue
Zhao, Ruifeng
Cheng, Yongxia
Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates
title Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates
title_full Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates
title_fullStr Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates
title_full_unstemmed Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates
title_short Study on the Influence of mRNA, the Genetic Language, on Protein Folding Rates
title_sort study on the influence of mrna, the genetic language, on protein folding rates
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056030/
https://www.ncbi.nlm.nih.gov/pubmed/33889178
http://dx.doi.org/10.3389/fgene.2021.635250
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