Cargando…

The Nuclear Farnesoid X Receptor Reduces p53 Ubiquitination and Inhibits Cervical Cancer Cell Proliferation

The role of farnesoid X receptor (FXR) in cervical cancer and the underlying molecular mechanism remain largely unknown. Therefore, this study aimed to assess the mechanism of FXR in cervical cancer. Western blot, qRT-PCR, and immunohistochemistry demonstrated that FXR was significantly reduced in s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Xiaohua, Wang, Bin, Chen, Runji, Zhong, Shuping, Gao, Fenfei, Zhang, Yanmei, Niu, Yongdong, Li, Congzhu, Shi, Ganggang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056046/ https://www.ncbi.nlm.nih.gov/pubmed/33889569 http://dx.doi.org/10.3389/fcell.2021.583146

Ejemplares similares

Farnesoid X receptor functions in cervical cancer via the p14(ARF)-mouse double minute 2-p53 pathway
por: Huang, Xiaohua, et al.
Publicado: (2022)

Arbutin Alleviates the Liver Injury of α-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation
por: Wu, Peijie, et al.
Publicado: (2021)

The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28
por: Liu, Yunshan, et al.
Publicado: (2022)

Editorial: Regulation of Ubiquitination and Sumoylation Signaling in Disease
por: Lin, Zhenghong, et al.
Publicado: (2022)

RNF180 Inhibits Proliferation and Promotes Apoptosis of Colorectal Cancer Through Ubiquitination of WISP1
por: Wei, Feng, et al.
Publicado: (2021)

PATZ1 (MAZR) Co-occupies Genomic Sites With p53 and Inhibits Liver Cancer Cell Proliferation via Regulating p27
por: Ng, Zhen Long, et al.
Publicado: (2021)

ERK5 and Cell Proliferation: Nuclear Localization Is What Matters
por: Gomez, Nestor, et al.
Publicado: (2016)

Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway
por: Wang, Bin, et al.
Publicado: (2021)

Corrigendum to “Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway”
por: Wang, Bin, et al.
Publicado: (2021)

When PIP(2) Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response
por: Wang, Yu-Hsiu, et al.
Publicado: (2022)

Hypoxia-Induced ZWINT Mediates Pancreatic Cancer Proliferation by Interacting With p53/p21
por: Chen, Peng, et al.
Publicado: (2021)

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
por: Li, Guodong, et al.
Publicado: (2015)

FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway
por: Che, Xiaoxia, et al.
Publicado: (2020)

CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy
por: Gong, Liyan, et al.
Publicado: (2021)

Unanchored Ubiquitin Chains, Revisited
por: Blount, Jessica R., et al.
Publicado: (2020)

Regulation of Ferroptosis Pathway by Ubiquitination
por: Wang, Xinbo, et al.
Publicado: (2021)

The Farnesoid X Receptor: Good for BAD
por: Keely, Stephen J., et al.
Publicado: (2016)

Cullin3-TNFAIP1 E3 Ligase Controls Inflammatory Response in Hepatocellular Carcinoma Cells via Ubiquitination of RhoB
por: Liu, Yue, et al.
Publicado: (2021)

Mitochondrial Quality Control Governed by Ubiquitin
por: Ravanelli, Sonia, et al.
Publicado: (2020)

LncRNA RP11-499E18.1 Inhibits Proliferation, Migration, and Epithelial–Mesenchymal Transition Process of Ovarian Cancer Cells by Dissociating PAK2–SOX2 Interaction
por: Yang, Juan, et al.
Publicado: (2021)

Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer
por: Shen, Aling, et al.
Publicado: (2022)

Ubiquitin Modification Patterns of Clear Cell Renal Cell Carcinoma and the Ubiquitin Score to Aid Immunotherapy and Targeted Therapy
por: Zhou, Peng, et al.
Publicado: (2021)

BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer
por: Zhao, Ran, et al.
Publicado: (2021)

Tools for Decoding Ubiquitin Signaling in DNA Repair
por: Foster, Benjamin, et al.
Publicado: (2021)

Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis
por: Yin, Xiu, et al.
Publicado: (2022)

Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN
por: LIU, JUN, et al.
Publicado: (2014)

Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension
por: Imig, John D.
Publicado: (2023)

Farnesoid X receptor (FXR): Structures and ligands
por: Jiang, Longying, et al.
Publicado: (2021)

Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway
por: Zhang, Manying, et al.
Publicado: (2020)

ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype
por: Olea-Flores, Monserrat, et al.
Publicado: (2022)

N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway
por: Lu, Shishi, et al.
Publicado: (2017)

N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells
por: Lu, Binger, et al.
Publicado: (2016)

Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer
por: Chen, Jing, et al.
Publicado: (2021)

Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
por: Zhu, Jinshun, et al.
Publicado: (2021)

Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
por: Kocaturk, Nur Mehpare, et al.
Publicado: (2018)

Ubiquitination as a Key Regulator of Endosomal Signaling by GPCRs
por: Burton, Jeremy C., et al.
Publicado: (2019)

Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases
por: Zhu, Wenjing, et al.
Publicado: (2021)

Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer
por: Song, Ying-Qi, et al.
Publicado: (2021)

The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance
por: Yuan, Lei, et al.
Publicado: (2022)

Function and regulation of ubiquitin-like SUMO system in heart
por: Wang, Ying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kt91p1gcegk16u13dbtamsciij