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Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure

The relationship between the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and the gut microbiota is poorly understood, and an HBV-ACLF-related microbiome has yet to be identified. In this study alterations in the fecal microbiome of 91 patients with HBV-ACLF (10...

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Autores principales: Yao, Xuebing, Yu, Haiping, Fan, Guoyin, Xiang, Haihong, Long, Lin, Xu, Huili, Wu, Zhiguo, Chen, Mingfa, Xi, Wenna, Gao, Zhen, Liu, Cuiyun, Gong, Wenlan, Yang, Aoyu, Sun, Ke, Yu, Rongyan, Liang, Junrong, Xie, Baogang, Sun, Shuilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056260/
https://www.ncbi.nlm.nih.gov/pubmed/33889550
http://dx.doi.org/10.3389/fcimb.2021.573923
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author Yao, Xuebing
Yu, Haiping
Fan, Guoyin
Xiang, Haihong
Long, Lin
Xu, Huili
Wu, Zhiguo
Chen, Mingfa
Xi, Wenna
Gao, Zhen
Liu, Cuiyun
Gong, Wenlan
Yang, Aoyu
Sun, Ke
Yu, Rongyan
Liang, Junrong
Xie, Baogang
Sun, Shuilin
author_facet Yao, Xuebing
Yu, Haiping
Fan, Guoyin
Xiang, Haihong
Long, Lin
Xu, Huili
Wu, Zhiguo
Chen, Mingfa
Xi, Wenna
Gao, Zhen
Liu, Cuiyun
Gong, Wenlan
Yang, Aoyu
Sun, Ke
Yu, Rongyan
Liang, Junrong
Xie, Baogang
Sun, Shuilin
author_sort Yao, Xuebing
collection PubMed
description The relationship between the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and the gut microbiota is poorly understood, and an HBV-ACLF-related microbiome has yet to be identified. In this study alterations in the fecal microbiome of 91 patients with HBV-ACLF (109 stool samples), including a cohort of nine patients at different stages of HBV-ACLF, were determined by high-throughput 16S rDNA sequencing. The operational taxonomic units and Shannon indexes indicated that the diversity and abundance of the gut microbiome significantly decreased with the progression of HBV-ACLF (p <0.05). The relative abundance of the Bacteroidetes phylum in the microbiome was significantly reduced, whereas the abundance of potentially pathogenic bacteria, such as Veilonella, Streptococcus, Enterococcus, and Klebsiella, was highly enriched in the HBV-ACLF group compared with the healthy control group. The abundance of Bacteroidetes was negatively correlated with the level of serum alpha fetoprotein, and the abundance of Veilonella was positively correlated with serum total bilirubin (TBIL). Furthermore, the abundance of Coprococcus was significantly negatively correlated with the level of serum TBIL and the international normalized ratio and positively correlated with prothrombin time activity. Our findings suggest that the gut microbiota plays an important role in the development of HBV-ACLF.
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spelling pubmed-80562602021-04-21 Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure Yao, Xuebing Yu, Haiping Fan, Guoyin Xiang, Haihong Long, Lin Xu, Huili Wu, Zhiguo Chen, Mingfa Xi, Wenna Gao, Zhen Liu, Cuiyun Gong, Wenlan Yang, Aoyu Sun, Ke Yu, Rongyan Liang, Junrong Xie, Baogang Sun, Shuilin Front Cell Infect Microbiol Cellular and Infection Microbiology The relationship between the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and the gut microbiota is poorly understood, and an HBV-ACLF-related microbiome has yet to be identified. In this study alterations in the fecal microbiome of 91 patients with HBV-ACLF (109 stool samples), including a cohort of nine patients at different stages of HBV-ACLF, were determined by high-throughput 16S rDNA sequencing. The operational taxonomic units and Shannon indexes indicated that the diversity and abundance of the gut microbiome significantly decreased with the progression of HBV-ACLF (p <0.05). The relative abundance of the Bacteroidetes phylum in the microbiome was significantly reduced, whereas the abundance of potentially pathogenic bacteria, such as Veilonella, Streptococcus, Enterococcus, and Klebsiella, was highly enriched in the HBV-ACLF group compared with the healthy control group. The abundance of Bacteroidetes was negatively correlated with the level of serum alpha fetoprotein, and the abundance of Veilonella was positively correlated with serum total bilirubin (TBIL). Furthermore, the abundance of Coprococcus was significantly negatively correlated with the level of serum TBIL and the international normalized ratio and positively correlated with prothrombin time activity. Our findings suggest that the gut microbiota plays an important role in the development of HBV-ACLF. Frontiers Media S.A. 2021-04-06 /pmc/articles/PMC8056260/ /pubmed/33889550 http://dx.doi.org/10.3389/fcimb.2021.573923 Text en Copyright © 2021 Yao, Yu, Fan, Xiang, Long, Xu, Wu, Chen, Xi, Gao, Liu, Gong, Yang, Sun, Yu, Liang, Xie and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Yao, Xuebing
Yu, Haiping
Fan, Guoyin
Xiang, Haihong
Long, Lin
Xu, Huili
Wu, Zhiguo
Chen, Mingfa
Xi, Wenna
Gao, Zhen
Liu, Cuiyun
Gong, Wenlan
Yang, Aoyu
Sun, Ke
Yu, Rongyan
Liang, Junrong
Xie, Baogang
Sun, Shuilin
Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
title Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
title_full Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
title_fullStr Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
title_full_unstemmed Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
title_short Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
title_sort impact of the gut microbiome on the progression of hepatitis b virus related acute-on-chronic liver failure
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056260/
https://www.ncbi.nlm.nih.gov/pubmed/33889550
http://dx.doi.org/10.3389/fcimb.2021.573923
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