Entropic Inhibition: How the Activity of a AAA+ Machine Is Modulated by Its Substrate-Binding Domain

[Image: see text] ClpB is a tightly regulated AAA+ disaggregation machine. Each ClpB molecule is composed of a flexibly attached N-terminal domain (NTD), an essential middle domain (MD) that activates the machine by tilting, and two nucleotide-binding domains. The NTD is not well-characterized struc...

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Detalles Bibliográficos
Autores principales: Iljina, Marija, Mazal, Hisham, Goloubinoff, Pierre, Riven, Inbal, Haran, Gilad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056383/
https://www.ncbi.nlm.nih.gov/pubmed/33739813
http://dx.doi.org/10.1021/acschembio.1c00156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056383/
https://www.ncbi.nlm.nih.gov/pubmed/33739813
http://dx.doi.org/10.1021/acschembio.1c00156

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