Synthetic (N,N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs

[Image: see text] Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two molecular modes of action: DNA double-strand break formation (through topoisomerase IIα poisoning) and...

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Detalles Bibliográficos
Autores principales: Wander, Dennis P. A., van der Zanden, Sabina Y., Vriends, Merijn B. L., van Veen, Branca C., Vlaming, Joey G. C., Bruyning, Thomas, Hansen, Thomas, van der Marel, Gijsbert A., Overkleeft, Herman S., Neefjes, Jacques J. C., Codée, Jeroen D. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056385/
https://www.ncbi.nlm.nih.gov/pubmed/33783212
http://dx.doi.org/10.1021/acs.joc.1c00220

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