Cargando…

The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model

Chrysobalanus orbicularis is a medicinal plant present in West Africa in the Itsekiri speaking part of Nigeria. It is used conventionally in diabetes mellitus management. This research investigates the ameliorative activity of the aqueous leaf extract of C. orbicularis in a streptozotocin-induced di...

Descripción completa

Detalles Bibliográficos
Autores principales: Ekakitie, Lisa Ilobekemen, Oyinloye, Babatunji Emmanuel, Ajiboye, Basiru Olaitan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056426/
https://www.ncbi.nlm.nih.gov/pubmed/33898800
http://dx.doi.org/10.1016/j.heliyon.2021.e06596
_version_ 1783680645492375552
author Ekakitie, Lisa Ilobekemen
Oyinloye, Babatunji Emmanuel
Ajiboye, Basiru Olaitan
author_facet Ekakitie, Lisa Ilobekemen
Oyinloye, Babatunji Emmanuel
Ajiboye, Basiru Olaitan
author_sort Ekakitie, Lisa Ilobekemen
collection PubMed
description Chrysobalanus orbicularis is a medicinal plant present in West Africa in the Itsekiri speaking part of Nigeria. It is used conventionally in diabetes mellitus management. This research investigates the ameliorative activity of the aqueous leaf extract of C. orbicularis in a streptozotocin-induced diabetic rat model. Freshly prepared streptozotocin (40 mg/kg body weight [BW]) was administered intraperitoneally to induce diabetes. Three diabetic groups were placed on aqueous leaf extract of C. orbicularis at 11.076, 22.134, and 44.268 mg/kg BW respectively; a group was placed on metformin (44.28 mg/kg BW), and the other two groups were the diabetic control and normal control. The experiment lasted for 28 days, thereafter, fasting blood glucose levels and body weight variations were recorded. Also, glycogen level, antioxidant enzyme, hexokinase and glucose-6-phosphatase activities, malonaldehyde (MDA) as well as glucose transporters 2 and 4 levels were analyzed using standard procedures. Diabetic rats administered aqueous extract of C. orbicularis leaf significantly (p < 0.05) decreased the fasting blood glucose and MDA levels, and glucose-6-phosphatase activity. In addition, administration of aqueous extract of C. orbicularis leaf to diabetic rats demonstrated a momentous increase in liver glycogen level, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, glutathione transferase, and hexokinase activities as well as GLUT-2 and GLUT-4 levels. The data from this study suggest that the aqueous extract of C. orbicularis leaf may be beneficial in the management of diabetic mellitus and its secondary effects.
format Online
Article
Text
id pubmed-8056426
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-80564262021-04-23 The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model Ekakitie, Lisa Ilobekemen Oyinloye, Babatunji Emmanuel Ajiboye, Basiru Olaitan Heliyon Research Article Chrysobalanus orbicularis is a medicinal plant present in West Africa in the Itsekiri speaking part of Nigeria. It is used conventionally in diabetes mellitus management. This research investigates the ameliorative activity of the aqueous leaf extract of C. orbicularis in a streptozotocin-induced diabetic rat model. Freshly prepared streptozotocin (40 mg/kg body weight [BW]) was administered intraperitoneally to induce diabetes. Three diabetic groups were placed on aqueous leaf extract of C. orbicularis at 11.076, 22.134, and 44.268 mg/kg BW respectively; a group was placed on metformin (44.28 mg/kg BW), and the other two groups were the diabetic control and normal control. The experiment lasted for 28 days, thereafter, fasting blood glucose levels and body weight variations were recorded. Also, glycogen level, antioxidant enzyme, hexokinase and glucose-6-phosphatase activities, malonaldehyde (MDA) as well as glucose transporters 2 and 4 levels were analyzed using standard procedures. Diabetic rats administered aqueous extract of C. orbicularis leaf significantly (p < 0.05) decreased the fasting blood glucose and MDA levels, and glucose-6-phosphatase activity. In addition, administration of aqueous extract of C. orbicularis leaf to diabetic rats demonstrated a momentous increase in liver glycogen level, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, glutathione transferase, and hexokinase activities as well as GLUT-2 and GLUT-4 levels. The data from this study suggest that the aqueous extract of C. orbicularis leaf may be beneficial in the management of diabetic mellitus and its secondary effects. Elsevier 2021-04-07 /pmc/articles/PMC8056426/ /pubmed/33898800 http://dx.doi.org/10.1016/j.heliyon.2021.e06596 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Ekakitie, Lisa Ilobekemen
Oyinloye, Babatunji Emmanuel
Ajiboye, Basiru Olaitan
The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model
title The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model
title_full The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model
title_fullStr The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model
title_full_unstemmed The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model
title_short The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model
title_sort ameliorative activity of chrysobalanus orbicularis in streptozotocin-induced type ii diabetes mellitus rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056426/
https://www.ncbi.nlm.nih.gov/pubmed/33898800
http://dx.doi.org/10.1016/j.heliyon.2021.e06596
work_keys_str_mv AT ekakitielisailobekemen theameliorativeactivityofchrysobalanusorbicularisinstreptozotocininducedtypeiidiabetesmellitusratmodel
AT oyinloyebabatunjiemmanuel theameliorativeactivityofchrysobalanusorbicularisinstreptozotocininducedtypeiidiabetesmellitusratmodel
AT ajiboyebasiruolaitan theameliorativeactivityofchrysobalanusorbicularisinstreptozotocininducedtypeiidiabetesmellitusratmodel
AT ekakitielisailobekemen ameliorativeactivityofchrysobalanusorbicularisinstreptozotocininducedtypeiidiabetesmellitusratmodel
AT oyinloyebabatunjiemmanuel ameliorativeactivityofchrysobalanusorbicularisinstreptozotocininducedtypeiidiabetesmellitusratmodel
AT ajiboyebasiruolaitan ameliorativeactivityofchrysobalanusorbicularisinstreptozotocininducedtypeiidiabetesmellitusratmodel