COVID-19-related myocarditis post-heart transplantation

This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography ang...

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Autores principales: Roest, Stefan, Brugts, Jasper J., van Kampen, Jeroen J.A., von der Thüsen, Jan H., Constantinescu, Alina A., Caliskan, Kadir, Hirsch, Alexander, Manintveld, Olivier C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056480/
https://www.ncbi.nlm.nih.gov/pubmed/33862215
http://dx.doi.org/10.1016/j.ijid.2021.04.013
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author Roest, Stefan
Brugts, Jasper J.
van Kampen, Jeroen J.A.
von der Thüsen, Jan H.
Constantinescu, Alina A.
Caliskan, Kadir
Hirsch, Alexander
Manintveld, Olivier C.
author_facet Roest, Stefan
Brugts, Jasper J.
van Kampen, Jeroen J.A.
von der Thüsen, Jan H.
Constantinescu, Alina A.
Caliskan, Kadir
Hirsch, Alexander
Manintveld, Olivier C.
author_sort Roest, Stefan
collection PubMed
description This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography angiography did not show cardiac allograft vasculopathy, and myocardial biopsy demonstrated no clinically relevant rejection. Subsequent cardiovascular magnetic resonance imaging revealed extensive epicardial delayed enhancement without myocardial edema. Heart failure medication was initiated and an implantable cardioverter defibrillator was implanted (due to non-sustained ventricular tachycardias), leading to a partial recovery of the ejection fraction. Further studies are needed to investigate the number of heart transplant recipients with myocardial damage after a SARS-CoV-2 infection.
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spelling pubmed-80564802021-04-20 COVID-19-related myocarditis post-heart transplantation Roest, Stefan Brugts, Jasper J. van Kampen, Jeroen J.A. von der Thüsen, Jan H. Constantinescu, Alina A. Caliskan, Kadir Hirsch, Alexander Manintveld, Olivier C. Int J Infect Dis Article This report describes the first heart transplantation recipient with acute biventricular heart failure symptoms caused by a post-myocarditis state, late after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No other viral pathogens could be detected. Computed tomography angiography did not show cardiac allograft vasculopathy, and myocardial biopsy demonstrated no clinically relevant rejection. Subsequent cardiovascular magnetic resonance imaging revealed extensive epicardial delayed enhancement without myocardial edema. Heart failure medication was initiated and an implantable cardioverter defibrillator was implanted (due to non-sustained ventricular tachycardias), leading to a partial recovery of the ejection fraction. Further studies are needed to investigate the number of heart transplant recipients with myocardial damage after a SARS-CoV-2 infection. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-06 2021-04-20 /pmc/articles/PMC8056480/ /pubmed/33862215 http://dx.doi.org/10.1016/j.ijid.2021.04.013 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Roest, Stefan
Brugts, Jasper J.
van Kampen, Jeroen J.A.
von der Thüsen, Jan H.
Constantinescu, Alina A.
Caliskan, Kadir
Hirsch, Alexander
Manintveld, Olivier C.
COVID-19-related myocarditis post-heart transplantation
title COVID-19-related myocarditis post-heart transplantation
title_full COVID-19-related myocarditis post-heart transplantation
title_fullStr COVID-19-related myocarditis post-heart transplantation
title_full_unstemmed COVID-19-related myocarditis post-heart transplantation
title_short COVID-19-related myocarditis post-heart transplantation
title_sort covid-19-related myocarditis post-heart transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056480/
https://www.ncbi.nlm.nih.gov/pubmed/33862215
http://dx.doi.org/10.1016/j.ijid.2021.04.013
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