Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

BACKGROUND: Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ischemia (tGCI). Although mixed lineage kinase domain-like (MLKL) has emerged as a c...

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Detalles Bibliográficos
Autores principales: Zhan, Lixuan, Lu, Xiaomei, Xu, Wensheng, Sun, Weiwen, Xu, En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056617/
https://www.ncbi.nlm.nih.gov/pubmed/33879157
http://dx.doi.org/10.1186/s12974-021-02141-y

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