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scMET: Bayesian modeling of DNA methylation heterogeneity at single-cell resolution

High-throughput single-cell measurements of DNA methylomes can quantify methylation heterogeneity and uncover its role in gene regulation. However, technical limitations and sparse coverage can preclude this task. scMET is a hierarchical Bayesian model which overcomes sparsity, sharing information a...

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Detalles Bibliográficos
Autores principales:	Kapourani, Chantriolnt-Andreas, Argelaguet, Ricard, Sanguinetti, Guido, Vallejos, Catalina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056718/ https://www.ncbi.nlm.nih.gov/pubmed/33879195 http://dx.doi.org/10.1186/s13059-021-02329-8

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