Cargando…
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude
Gaining a mechanistic understanding of the expansion and maturation program of natural killer (NK) cells will provide opportunities for harnessing their inflammation-inducing and oncolytic capacity for therapeutic purposes. Here, we demonstrated that ID2, a transcriptional regulatory protein constit...
Autores principales: | Li, Zhong-Yin, Morman, Rosemary E., Hegermiller, Emma, Sun, Mengxi, Bartom, Elizabeth T., Maienschein-Cline, Mark, Sigvardsson, Mikael, Kee, Barbara L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056751/ https://www.ncbi.nlm.nih.gov/pubmed/33857289 http://dx.doi.org/10.1084/jem.20202032 |
Ejemplares similares
-
Tcf7l2/Tcf4 Transcriptional Repressor Function Requires HDAC Activity in the Developing Vertebrate CNS
por: Wang, Hui, et al.
Publicado: (2016) -
Editorial: Molecular switches of the immune system: The E-protein/Id axis in hematopoietic development and function
por: Sigvardsson, Mikael, et al.
Publicado: (2022) -
Mature natural killer cell and lymphoid tissue–inducing cell development requires Id2-mediated suppression of E protein activity
por: Boos, Markus D., et al.
Publicado: (2007) -
Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation
por: Young, Rodrigo M, et al.
Publicado: (2019) -
Acetylation of Human TCF4 (TCF7L2) Proteins Attenuates Inhibition by the HBP1 Repressor and Induces a Conformational Change in the TCF4::DNA Complex
por: Elfert, Susanne, et al.
Publicado: (2013)