PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the blood system in response to inflammatory cues; however, excessive proliferation in response to chronic inflammation can lead to either HSC attrition or expansion. The mechanism(s) that limit HSC proliferation and...

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Detalles Bibliográficos
Autores principales: Chavez, James S., Rabe, Jennifer L., Loeffler, Dirk, Higa, Kelly C., Hernandez, Giovanny, Mills, Taylor S., Ahmed, Nouraiz, Gessner, Rachel L., Ke, Zhonghe, Idler, Beau M., Niño, Katia E., Kim, Hyunmin, Myers, Jason R., Stevens, Brett M., Davizon-Castillo, Pavel, Jordan, Craig T., Nakajima, Hideaki, Ashton, John, Welner, Robert S., Schroeder, Timm, DeGregori, James, Pietras, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056754/
https://www.ncbi.nlm.nih.gov/pubmed/33857288
http://dx.doi.org/10.1084/jem.20201169

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