Cargando…

Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy

Ernest Starling first presented a hypothesis about the absorption of tissue fluid to the plasma within tissue capillaries in 1896. In this Chapter we trace the evolution of Starling's hypothesis to a principle and an equation, and then look in more detail at the extension of the Starling princi...

Descripción completa

Detalles Bibliográficos
Autores principales: Woodcock, Thomas E., Michel, C. Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056939/
https://www.ncbi.nlm.nih.gov/pubmed/33889604
http://dx.doi.org/10.3389/fvets.2021.623671
_version_ 1783680751355559936
author Woodcock, Thomas E.
Michel, C. Charles
author_facet Woodcock, Thomas E.
Michel, C. Charles
author_sort Woodcock, Thomas E.
collection PubMed
description Ernest Starling first presented a hypothesis about the absorption of tissue fluid to the plasma within tissue capillaries in 1896. In this Chapter we trace the evolution of Starling's hypothesis to a principle and an equation, and then look in more detail at the extension of the Starling principle in recent years. In 2012 Thomas Woodcock and his son proposed that experience and experimental observations surrounding clinical practices involving the administration of intravenous fluids were better explained by the revised Starling principle. In particular, the revised or extended Starling principle can explain why crystalloid resuscitation from the abrupt physiologic insult of hypovolaemia is much more effective than the pre-revision Starling principle had led clinicians to expect. The authors of this chapter have since combined their science and clinical expertise to offer clinicians a better basis for their practice of rational fluid therapy.
format Online
Article
Text
id pubmed-8056939
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80569392021-04-21 Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy Woodcock, Thomas E. Michel, C. Charles Front Vet Sci Veterinary Science Ernest Starling first presented a hypothesis about the absorption of tissue fluid to the plasma within tissue capillaries in 1896. In this Chapter we trace the evolution of Starling's hypothesis to a principle and an equation, and then look in more detail at the extension of the Starling principle in recent years. In 2012 Thomas Woodcock and his son proposed that experience and experimental observations surrounding clinical practices involving the administration of intravenous fluids were better explained by the revised Starling principle. In particular, the revised or extended Starling principle can explain why crystalloid resuscitation from the abrupt physiologic insult of hypovolaemia is much more effective than the pre-revision Starling principle had led clinicians to expect. The authors of this chapter have since combined their science and clinical expertise to offer clinicians a better basis for their practice of rational fluid therapy. Frontiers Media S.A. 2021-04-06 /pmc/articles/PMC8056939/ /pubmed/33889604 http://dx.doi.org/10.3389/fvets.2021.623671 Text en Copyright © 2021 Woodcock and Michel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Woodcock, Thomas E.
Michel, C. Charles
Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy
title Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy
title_full Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy
title_fullStr Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy
title_full_unstemmed Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy
title_short Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy
title_sort advances in the starling principle and microvascular fluid exchange; consequences and implications for fluid therapy
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056939/
https://www.ncbi.nlm.nih.gov/pubmed/33889604
http://dx.doi.org/10.3389/fvets.2021.623671
work_keys_str_mv AT woodcockthomase advancesinthestarlingprincipleandmicrovascularfluidexchangeconsequencesandimplicationsforfluidtherapy
AT michelccharles advancesinthestarlingprincipleandmicrovascularfluidexchangeconsequencesandimplicationsforfluidtherapy