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Web resources facilitate drug discovery in treatment of COVID-19

The infectious disease Coronavirus 2019 (COVID-19) continues to cause a global pandemic and, thus, the need for effective therapeutics remains urgent. Global research targeting COVID-19 treatments has produced numerous therapy-related data and established data repositories. However, these data are d...

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Detalles Bibliográficos
Autores principales: Mei, Long-Can, Jin, Yin, Wang, Zheng, Hao, Ge-Fei, Yang, Guang-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056987/
https://www.ncbi.nlm.nih.gov/pubmed/33892145
http://dx.doi.org/10.1016/j.drudis.2021.04.018
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author Mei, Long-Can
Jin, Yin
Wang, Zheng
Hao, Ge-Fei
Yang, Guang-Fu
author_facet Mei, Long-Can
Jin, Yin
Wang, Zheng
Hao, Ge-Fei
Yang, Guang-Fu
author_sort Mei, Long-Can
collection PubMed
description The infectious disease Coronavirus 2019 (COVID-19) continues to cause a global pandemic and, thus, the need for effective therapeutics remains urgent. Global research targeting COVID-19 treatments has produced numerous therapy-related data and established data repositories. However, these data are disseminated throughout the literature and web resources, which could lead to a reduction in the levels of their use. In this review, we introduce resource repositories for the development of COVID-19 therapeutics, from the genome and proteome to antiviral drugs, vaccines, and monoclonal antibodies. We briefly describe the data and usage, and how they advance research for therapies. Finally, we discuss the opportunities and challenges to preventing the pandemic from developing further.
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spelling pubmed-80569872021-04-21 Web resources facilitate drug discovery in treatment of COVID-19 Mei, Long-Can Jin, Yin Wang, Zheng Hao, Ge-Fei Yang, Guang-Fu Drug Discov Today Informatics (Orange) The infectious disease Coronavirus 2019 (COVID-19) continues to cause a global pandemic and, thus, the need for effective therapeutics remains urgent. Global research targeting COVID-19 treatments has produced numerous therapy-related data and established data repositories. However, these data are disseminated throughout the literature and web resources, which could lead to a reduction in the levels of their use. In this review, we introduce resource repositories for the development of COVID-19 therapeutics, from the genome and proteome to antiviral drugs, vaccines, and monoclonal antibodies. We briefly describe the data and usage, and how they advance research for therapies. Finally, we discuss the opportunities and challenges to preventing the pandemic from developing further. Elsevier Ltd. 2021-10 2021-04-20 /pmc/articles/PMC8056987/ /pubmed/33892145 http://dx.doi.org/10.1016/j.drudis.2021.04.018 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Informatics (Orange)
Mei, Long-Can
Jin, Yin
Wang, Zheng
Hao, Ge-Fei
Yang, Guang-Fu
Web resources facilitate drug discovery in treatment of COVID-19
title Web resources facilitate drug discovery in treatment of COVID-19
title_full Web resources facilitate drug discovery in treatment of COVID-19
title_fullStr Web resources facilitate drug discovery in treatment of COVID-19
title_full_unstemmed Web resources facilitate drug discovery in treatment of COVID-19
title_short Web resources facilitate drug discovery in treatment of COVID-19
title_sort web resources facilitate drug discovery in treatment of covid-19
topic Informatics (Orange)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056987/
https://www.ncbi.nlm.nih.gov/pubmed/33892145
http://dx.doi.org/10.1016/j.drudis.2021.04.018
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