IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

BACKGROUND: Immunosuppressive and anti-cytokine treatment may have a protective effect for patients with COVID-19. Understanding the immune cell states shared between COVID-19 and other inflammatory diseases with established therapies may help nominate immunomodulatory therapies. METHODS: To identif...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Fan, Mears, Joseph R., Shakib, Lorien, Beynor, Jessica I., Shanaj, Sara, Korsunsky, Ilya, Nathan, Aparna, Donlin, Laura T., Raychaudhuri, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057009/
https://www.ncbi.nlm.nih.gov/pubmed/33879239
http://dx.doi.org/10.1186/s13073-021-00881-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057009/
https://www.ncbi.nlm.nih.gov/pubmed/33879239
http://dx.doi.org/10.1186/s13073-021-00881-3

Ejemplares similares