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The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator

Cholinergic efferent networks located from the medial septal nucleus to the hippocampus play a pivotal role in learning and memory outcomes by generating regular theta rhythms that enhance information retention. Hippocampal cholinergic neurostimulating peptide (HCNP), derived from the N-terminus of...

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Autores principales: Cho, Justin Y., Matsukawa, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057103/
https://www.ncbi.nlm.nih.gov/pubmed/34084974
http://dx.doi.org/10.4103/bc.bc_14_21
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author Cho, Justin Y.
Matsukawa, Noriyuki
author_facet Cho, Justin Y.
Matsukawa, Noriyuki
author_sort Cho, Justin Y.
collection PubMed
description Cholinergic efferent networks located from the medial septal nucleus to the hippocampus play a pivotal role in learning and memory outcomes by generating regular theta rhythms that enhance information retention. Hippocampal cholinergic neurostimulating peptide (HCNP), derived from the N-terminus of HCNP precursor protein (HCNP-pp), promotes the synthesis of acetylcholine in the medial septal nuclei. HCNP-pp deletion significantly reduced theta power in CA1 possibly due to lower levels of choline acetyltransferase-positive axons in CA1 stratum oriens, suggesting cholinergic disruptions in the septo-hippocampal system. This review also explores HCNP as a potent cholinergic regulator in the septo-hippocampal network while also examining the limitations of our understanding of the neurostimulating peptide.
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spelling pubmed-80571032021-06-02 The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator Cho, Justin Y. Matsukawa, Noriyuki Brain Circ Review Article Cholinergic efferent networks located from the medial septal nucleus to the hippocampus play a pivotal role in learning and memory outcomes by generating regular theta rhythms that enhance information retention. Hippocampal cholinergic neurostimulating peptide (HCNP), derived from the N-terminus of HCNP precursor protein (HCNP-pp), promotes the synthesis of acetylcholine in the medial septal nuclei. HCNP-pp deletion significantly reduced theta power in CA1 possibly due to lower levels of choline acetyltransferase-positive axons in CA1 stratum oriens, suggesting cholinergic disruptions in the septo-hippocampal system. This review also explores HCNP as a potent cholinergic regulator in the septo-hippocampal network while also examining the limitations of our understanding of the neurostimulating peptide. Wolters Kluwer - Medknow 2021-03-30 /pmc/articles/PMC8057103/ /pubmed/34084974 http://dx.doi.org/10.4103/bc.bc_14_21 Text en Copyright: © 2021 Brain Circulation https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Cho, Justin Y.
Matsukawa, Noriyuki
The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
title The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
title_full The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
title_fullStr The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
title_full_unstemmed The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
title_short The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
title_sort unsolved mystery of hippocampal cholinergic neurostimulating peptide: a potent cholinergic regulator
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057103/
https://www.ncbi.nlm.nih.gov/pubmed/34084974
http://dx.doi.org/10.4103/bc.bc_14_21
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