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The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator
Cholinergic efferent networks located from the medial septal nucleus to the hippocampus play a pivotal role in learning and memory outcomes by generating regular theta rhythms that enhance information retention. Hippocampal cholinergic neurostimulating peptide (HCNP), derived from the N-terminus of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057103/ https://www.ncbi.nlm.nih.gov/pubmed/34084974 http://dx.doi.org/10.4103/bc.bc_14_21 |
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author | Cho, Justin Y. Matsukawa, Noriyuki |
author_facet | Cho, Justin Y. Matsukawa, Noriyuki |
author_sort | Cho, Justin Y. |
collection | PubMed |
description | Cholinergic efferent networks located from the medial septal nucleus to the hippocampus play a pivotal role in learning and memory outcomes by generating regular theta rhythms that enhance information retention. Hippocampal cholinergic neurostimulating peptide (HCNP), derived from the N-terminus of HCNP precursor protein (HCNP-pp), promotes the synthesis of acetylcholine in the medial septal nuclei. HCNP-pp deletion significantly reduced theta power in CA1 possibly due to lower levels of choline acetyltransferase-positive axons in CA1 stratum oriens, suggesting cholinergic disruptions in the septo-hippocampal system. This review also explores HCNP as a potent cholinergic regulator in the septo-hippocampal network while also examining the limitations of our understanding of the neurostimulating peptide. |
format | Online Article Text |
id | pubmed-8057103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-80571032021-06-02 The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator Cho, Justin Y. Matsukawa, Noriyuki Brain Circ Review Article Cholinergic efferent networks located from the medial septal nucleus to the hippocampus play a pivotal role in learning and memory outcomes by generating regular theta rhythms that enhance information retention. Hippocampal cholinergic neurostimulating peptide (HCNP), derived from the N-terminus of HCNP precursor protein (HCNP-pp), promotes the synthesis of acetylcholine in the medial septal nuclei. HCNP-pp deletion significantly reduced theta power in CA1 possibly due to lower levels of choline acetyltransferase-positive axons in CA1 stratum oriens, suggesting cholinergic disruptions in the septo-hippocampal system. This review also explores HCNP as a potent cholinergic regulator in the septo-hippocampal network while also examining the limitations of our understanding of the neurostimulating peptide. Wolters Kluwer - Medknow 2021-03-30 /pmc/articles/PMC8057103/ /pubmed/34084974 http://dx.doi.org/10.4103/bc.bc_14_21 Text en Copyright: © 2021 Brain Circulation https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Cho, Justin Y. Matsukawa, Noriyuki The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator |
title | The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator |
title_full | The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator |
title_fullStr | The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator |
title_full_unstemmed | The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator |
title_short | The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator |
title_sort | unsolved mystery of hippocampal cholinergic neurostimulating peptide: a potent cholinergic regulator |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057103/ https://www.ncbi.nlm.nih.gov/pubmed/34084974 http://dx.doi.org/10.4103/bc.bc_14_21 |
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