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Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria

The emergence of new SARS-CoV-2 variants with enhanced transmissibility or decreased susceptibility to immune responses is a major threat to global efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Disparities in viral genomic surveillance capabilities and efforts have resulted in gap...

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Autores principales: Ozer, Egon A., Simons, Lacy M., Adewumi, Olubusuyi M., Fowotade, Adeola A., Omoruyi, Ewean C., Adeniji, Johnson A., Dean, Taylor J., Zayas, Janet, Bhimalli, Pavan P., Ash, Michelle K., Godzik, Adam, Schneider, Jeffrey R., Mamede, João I., Taiwo, Babafemi O., Hultquist, Judd F., Lorenzo-Redondo, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057251/
https://www.ncbi.nlm.nih.gov/pubmed/33880483
http://dx.doi.org/10.1101/2021.04.09.21255206
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author Ozer, Egon A.
Simons, Lacy M.
Adewumi, Olubusuyi M.
Fowotade, Adeola A.
Omoruyi, Ewean C.
Adeniji, Johnson A.
Dean, Taylor J.
Zayas, Janet
Bhimalli, Pavan P.
Ash, Michelle K.
Godzik, Adam
Schneider, Jeffrey R.
Mamede, João I.
Taiwo, Babafemi O.
Hultquist, Judd F.
Lorenzo-Redondo, Ramon
author_facet Ozer, Egon A.
Simons, Lacy M.
Adewumi, Olubusuyi M.
Fowotade, Adeola A.
Omoruyi, Ewean C.
Adeniji, Johnson A.
Dean, Taylor J.
Zayas, Janet
Bhimalli, Pavan P.
Ash, Michelle K.
Godzik, Adam
Schneider, Jeffrey R.
Mamede, João I.
Taiwo, Babafemi O.
Hultquist, Judd F.
Lorenzo-Redondo, Ramon
author_sort Ozer, Egon A.
collection PubMed
description The emergence of new SARS-CoV-2 variants with enhanced transmissibility or decreased susceptibility to immune responses is a major threat to global efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Disparities in viral genomic surveillance capabilities and efforts have resulted in gaps in our understanding of the viral population dynamics across the globe. Nigeria, despite having the largest population of any nation in Africa, has had relatively little SARS-CoV-2 sequence data made publicly available. Here we report the whole-genome sequences of 74 SARS-CoV-2 isolates collected from individuals in Oyo State, Nigeria in January 2021. Most isolates belonged to either the B.1.1.7 Alpha “variant of concern” or the B.1.525 Eta lineage, which is currently considered a “variant of interest” containing multiple spike protein mutations previously associated with enhanced transmissibility and possible immune escape. Nigeria has the highest reported frequency of the B.1.525 lineage globally with phylogenetic characteristics consistent with a recent monophyletic origin and rapid expansion. Spike protein from the B.1.525 lineage displayed both increased infectivity and decreased neutralization by convalescent sera compared to Spike proteins from other clades. These results, along with indications that the virus is outpacing the B.1.1.7 lineage in Nigeria, suggest that the B.1.525 lineage represents another “variant of concern” and further underline the importance of genomic surveillance in undersampled regions across the globe.
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spelling pubmed-80572512021-04-21 Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria Ozer, Egon A. Simons, Lacy M. Adewumi, Olubusuyi M. Fowotade, Adeola A. Omoruyi, Ewean C. Adeniji, Johnson A. Dean, Taylor J. Zayas, Janet Bhimalli, Pavan P. Ash, Michelle K. Godzik, Adam Schneider, Jeffrey R. Mamede, João I. Taiwo, Babafemi O. Hultquist, Judd F. Lorenzo-Redondo, Ramon medRxiv Article The emergence of new SARS-CoV-2 variants with enhanced transmissibility or decreased susceptibility to immune responses is a major threat to global efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Disparities in viral genomic surveillance capabilities and efforts have resulted in gaps in our understanding of the viral population dynamics across the globe. Nigeria, despite having the largest population of any nation in Africa, has had relatively little SARS-CoV-2 sequence data made publicly available. Here we report the whole-genome sequences of 74 SARS-CoV-2 isolates collected from individuals in Oyo State, Nigeria in January 2021. Most isolates belonged to either the B.1.1.7 Alpha “variant of concern” or the B.1.525 Eta lineage, which is currently considered a “variant of interest” containing multiple spike protein mutations previously associated with enhanced transmissibility and possible immune escape. Nigeria has the highest reported frequency of the B.1.525 lineage globally with phylogenetic characteristics consistent with a recent monophyletic origin and rapid expansion. Spike protein from the B.1.525 lineage displayed both increased infectivity and decreased neutralization by convalescent sera compared to Spike proteins from other clades. These results, along with indications that the virus is outpacing the B.1.1.7 lineage in Nigeria, suggest that the B.1.525 lineage represents another “variant of concern” and further underline the importance of genomic surveillance in undersampled regions across the globe. Cold Spring Harbor Laboratory 2021-07-02 /pmc/articles/PMC8057251/ /pubmed/33880483 http://dx.doi.org/10.1101/2021.04.09.21255206 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Ozer, Egon A.
Simons, Lacy M.
Adewumi, Olubusuyi M.
Fowotade, Adeola A.
Omoruyi, Ewean C.
Adeniji, Johnson A.
Dean, Taylor J.
Zayas, Janet
Bhimalli, Pavan P.
Ash, Michelle K.
Godzik, Adam
Schneider, Jeffrey R.
Mamede, João I.
Taiwo, Babafemi O.
Hultquist, Judd F.
Lorenzo-Redondo, Ramon
Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria
title Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria
title_full Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria
title_fullStr Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria
title_full_unstemmed Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria
title_short Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria
title_sort coincident rapid expansion of two sars-cov-2 lineages with enhanced infectivity in nigeria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057251/
https://www.ncbi.nlm.nih.gov/pubmed/33880483
http://dx.doi.org/10.1101/2021.04.09.21255206
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