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Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA

The quality of a renal transplant can influence the clinical course after transplantation. Glomerular immune reactivity in renal transplants has previously been described, focusing particularly on IgA, and has been shown to disappear in most cases without affecting the outcome. Here, we describe a c...

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Autores principales: Vonbrunn, Eva, Serikova, Sofya, Daniel, Christoph, Amann, Kerstin, Schödel, Johannes, Buchholz, Björn, Ferrazzi, Fulvia, Heller, Katharina, Apel, Hendrik, Büttner-Herold, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057301/
https://www.ncbi.nlm.nih.gov/pubmed/33889588
http://dx.doi.org/10.3389/fmed.2021.656840
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author Vonbrunn, Eva
Serikova, Sofya
Daniel, Christoph
Amann, Kerstin
Schödel, Johannes
Buchholz, Björn
Ferrazzi, Fulvia
Heller, Katharina
Apel, Hendrik
Büttner-Herold, Maike
author_facet Vonbrunn, Eva
Serikova, Sofya
Daniel, Christoph
Amann, Kerstin
Schödel, Johannes
Buchholz, Björn
Ferrazzi, Fulvia
Heller, Katharina
Apel, Hendrik
Büttner-Herold, Maike
author_sort Vonbrunn, Eva
collection PubMed
description The quality of a renal transplant can influence the clinical course after transplantation. Glomerular immune reactivity in renal transplants has previously been described, focusing particularly on IgA, and has been shown to disappear in most cases without affecting the outcome. Here, we describe a cohort of time zero biopsies with regard to glomerular immune reactivity and implications for histomorphology and follow-up. 204 Time zero biopsies were analyzed by immunohistochemistry for glomerular immune reactivity. Time zero and 1-year biopsies were evaluated for histomorphological changes, which, together with clinical and follow-up data, were assessed for associations with glomerular immune profiles. Nearly half of the analyzed time zero biopsies showed glomerular immune reactivity with mesangial C3 being the most common (32.9%), followed by IgA (13.7%) and fullhouse patterns (6.9%). Strong C3 deposits (C3high) were only observed in deceased transplants. In the majority of cases immune reactivity was undetectable in follow-up biopsies and had no adverse effect on transplant function in follow-up of 5 years. In kidney pairs transplanted to different recipients a strong concordance of immune profiles in both kidneys was observed. Moreover, an association of male donor sex and deceased donor transplantation with the presence of immune reactivity was observed. In conclusion, glomerular immune reactivity is a very frequent finding in time zero biopsies, which seems to be determined by donor parameters including male sex and deceased donor transplants. It had no adverse impact on transplant function in 5-year follow-up. Glomerular immune reactivity in time zero biopsies, therefore, does not appear to indicate an inferior quality of the transplant.
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spelling pubmed-80573012021-04-21 Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA Vonbrunn, Eva Serikova, Sofya Daniel, Christoph Amann, Kerstin Schödel, Johannes Buchholz, Björn Ferrazzi, Fulvia Heller, Katharina Apel, Hendrik Büttner-Herold, Maike Front Med (Lausanne) Medicine The quality of a renal transplant can influence the clinical course after transplantation. Glomerular immune reactivity in renal transplants has previously been described, focusing particularly on IgA, and has been shown to disappear in most cases without affecting the outcome. Here, we describe a cohort of time zero biopsies with regard to glomerular immune reactivity and implications for histomorphology and follow-up. 204 Time zero biopsies were analyzed by immunohistochemistry for glomerular immune reactivity. Time zero and 1-year biopsies were evaluated for histomorphological changes, which, together with clinical and follow-up data, were assessed for associations with glomerular immune profiles. Nearly half of the analyzed time zero biopsies showed glomerular immune reactivity with mesangial C3 being the most common (32.9%), followed by IgA (13.7%) and fullhouse patterns (6.9%). Strong C3 deposits (C3high) were only observed in deceased transplants. In the majority of cases immune reactivity was undetectable in follow-up biopsies and had no adverse effect on transplant function in follow-up of 5 years. In kidney pairs transplanted to different recipients a strong concordance of immune profiles in both kidneys was observed. Moreover, an association of male donor sex and deceased donor transplantation with the presence of immune reactivity was observed. In conclusion, glomerular immune reactivity is a very frequent finding in time zero biopsies, which seems to be determined by donor parameters including male sex and deceased donor transplants. It had no adverse impact on transplant function in 5-year follow-up. Glomerular immune reactivity in time zero biopsies, therefore, does not appear to indicate an inferior quality of the transplant. Frontiers Media S.A. 2021-04-06 /pmc/articles/PMC8057301/ /pubmed/33889588 http://dx.doi.org/10.3389/fmed.2021.656840 Text en Copyright © 2021 Vonbrunn, Serikova, Daniel, Amann, Schödel, Buchholz, Ferrazzi, Heller, Apel and Büttner-Herold. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Vonbrunn, Eva
Serikova, Sofya
Daniel, Christoph
Amann, Kerstin
Schödel, Johannes
Buchholz, Björn
Ferrazzi, Fulvia
Heller, Katharina
Apel, Hendrik
Büttner-Herold, Maike
Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA
title Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA
title_full Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA
title_fullStr Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA
title_full_unstemmed Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA
title_short Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA
title_sort significance of glomerular immune reactivity in time zero biopsies for allograft survival beyond iga
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057301/
https://www.ncbi.nlm.nih.gov/pubmed/33889588
http://dx.doi.org/10.3389/fmed.2021.656840
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