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The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank
BACKGROUND: Systemic inflammation has been linked with mood disorder and cognitive impairment. The extent of this relationship remains uncertain, with the effects of serum inflammatory biomarkers compared to genetic predisposition toward inflammation yet to be clearly established. METHODS: We invest...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057439/ https://www.ncbi.nlm.nih.gov/pubmed/33517931 http://dx.doi.org/10.1192/j.eurpsy.2021.6 |
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author | Milton, David C. Ward, Joey Ward, Emilia Lyall, Donald M. Strawbridge, Rona J. Smith, Daniel J. Cullen, Breda |
author_facet | Milton, David C. Ward, Joey Ward, Emilia Lyall, Donald M. Strawbridge, Rona J. Smith, Daniel J. Cullen, Breda |
author_sort | Milton, David C. |
collection | PubMed |
description | BACKGROUND: Systemic inflammation has been linked with mood disorder and cognitive impairment. The extent of this relationship remains uncertain, with the effects of serum inflammatory biomarkers compared to genetic predisposition toward inflammation yet to be clearly established. METHODS: We investigated the magnitude of associations between C-reactive protein (CRP) measures, lifetime history of bipolar disorder or major depression, and cognitive function (reaction time and visuospatial memory) in 84,268 UK Biobank participants. CRP was measured in serum and a polygenic risk score for CRP was calculated, based on a published genome-wide association study. Multiple regression models adjusted for sociodemographic and clinical confounders. RESULTS: Increased serum CRP was significantly associated with mood disorder history (Kruskal–Wallis H = 196.06, p < 0.001, η(2) = 0.002) but increased polygenic risk for CRP was not (F = 0.668, p = 0.648, η(2) < 0.001). Compared to the lowest quintile, the highest serum CRP quintile was significantly associated with both negative and positive differences in cognitive performance (fully adjusted models: reaction time B = −0.030, 95% CI = −0.052, −0.008; visuospatial memory B = 0.066, 95% CI = 0.042, 0.089). More severe mood disorder categories were significantly associated with worse cognitive performance and this was not moderated by serum or genetic CRP level. CONCLUSIONS: In this large cohort study, we found that measured inflammation was associated with mood disorder history, but genetic predisposition to inflammation was not. The association between mood disorder and worse cognitive performance was very small and did not vary by CRP level. The inconsistent relationship between CRP measures and cognitive performance warrants further study. |
format | Online Article Text |
id | pubmed-8057439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80574392021-05-04 The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank Milton, David C. Ward, Joey Ward, Emilia Lyall, Donald M. Strawbridge, Rona J. Smith, Daniel J. Cullen, Breda Eur Psychiatry Research Article BACKGROUND: Systemic inflammation has been linked with mood disorder and cognitive impairment. The extent of this relationship remains uncertain, with the effects of serum inflammatory biomarkers compared to genetic predisposition toward inflammation yet to be clearly established. METHODS: We investigated the magnitude of associations between C-reactive protein (CRP) measures, lifetime history of bipolar disorder or major depression, and cognitive function (reaction time and visuospatial memory) in 84,268 UK Biobank participants. CRP was measured in serum and a polygenic risk score for CRP was calculated, based on a published genome-wide association study. Multiple regression models adjusted for sociodemographic and clinical confounders. RESULTS: Increased serum CRP was significantly associated with mood disorder history (Kruskal–Wallis H = 196.06, p < 0.001, η(2) = 0.002) but increased polygenic risk for CRP was not (F = 0.668, p = 0.648, η(2) < 0.001). Compared to the lowest quintile, the highest serum CRP quintile was significantly associated with both negative and positive differences in cognitive performance (fully adjusted models: reaction time B = −0.030, 95% CI = −0.052, −0.008; visuospatial memory B = 0.066, 95% CI = 0.042, 0.089). More severe mood disorder categories were significantly associated with worse cognitive performance and this was not moderated by serum or genetic CRP level. CONCLUSIONS: In this large cohort study, we found that measured inflammation was associated with mood disorder history, but genetic predisposition to inflammation was not. The association between mood disorder and worse cognitive performance was very small and did not vary by CRP level. The inconsistent relationship between CRP measures and cognitive performance warrants further study. Cambridge University Press 2021-02-01 /pmc/articles/PMC8057439/ /pubmed/33517931 http://dx.doi.org/10.1192/j.eurpsy.2021.6 Text en © The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Milton, David C. Ward, Joey Ward, Emilia Lyall, Donald M. Strawbridge, Rona J. Smith, Daniel J. Cullen, Breda The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank |
title | The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank |
title_full | The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank |
title_fullStr | The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank |
title_full_unstemmed | The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank |
title_short | The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank |
title_sort | association between c-reactive protein, mood disorder, and cognitive function in uk biobank |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057439/ https://www.ncbi.nlm.nih.gov/pubmed/33517931 http://dx.doi.org/10.1192/j.eurpsy.2021.6 |
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