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Biomarkers and indoor air quality: A translational research review

INTRODUCTION: Air pollution is linked to mortality and morbidity. Since humans spend nearly all their time indoors, improving indoor air quality (IAQ) is a compelling approach to mitigate air pollutant exposure. To assess interventions, relying on clinical outcomes may require prolonged follow-up, w...

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Autores principales: Senerat, Araliya M., Manemann, Sheila M., Clements, Nicholas S., Brook, Robert D., Hassett, Leslie C., Roger, Véronique L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057458/
https://www.ncbi.nlm.nih.gov/pubmed/33948261
http://dx.doi.org/10.1017/cts.2020.532
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author Senerat, Araliya M.
Manemann, Sheila M.
Clements, Nicholas S.
Brook, Robert D.
Hassett, Leslie C.
Roger, Véronique L.
author_facet Senerat, Araliya M.
Manemann, Sheila M.
Clements, Nicholas S.
Brook, Robert D.
Hassett, Leslie C.
Roger, Véronique L.
author_sort Senerat, Araliya M.
collection PubMed
description INTRODUCTION: Air pollution is linked to mortality and morbidity. Since humans spend nearly all their time indoors, improving indoor air quality (IAQ) is a compelling approach to mitigate air pollutant exposure. To assess interventions, relying on clinical outcomes may require prolonged follow-up, which hinders feasibility. Thus, identifying biomarkers that respond to changes in IAQ may be useful to assess the effectiveness of interventions. METHODS: We conducted a narrative review by searching several databases to identify studies published over the last decade that measured the response of blood, urine, and/or salivary biomarkers to variations (natural and intervention-induced) of changes in indoor air pollutant exposure. RESULTS: Numerous studies reported on associations between IAQ exposures and biomarkers with heterogeneity across study designs and methods. This review summarizes the responses of 113 biomarkers described in 30 articles. The biomarkers which most frequently responded to variations in indoor air pollutant exposures were high sensitivity C-reactive protein (hsCRP), von Willebrand Factor (vWF), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 1-hydroxypyrene (1-OHP). CONCLUSIONS: This review will guide the selection of biomarkers for translational studies evaluating the impact of indoor air pollutants on human health.
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spelling pubmed-80574582021-05-03 Biomarkers and indoor air quality: A translational research review Senerat, Araliya M. Manemann, Sheila M. Clements, Nicholas S. Brook, Robert D. Hassett, Leslie C. Roger, Véronique L. J Clin Transl Sci Research Article INTRODUCTION: Air pollution is linked to mortality and morbidity. Since humans spend nearly all their time indoors, improving indoor air quality (IAQ) is a compelling approach to mitigate air pollutant exposure. To assess interventions, relying on clinical outcomes may require prolonged follow-up, which hinders feasibility. Thus, identifying biomarkers that respond to changes in IAQ may be useful to assess the effectiveness of interventions. METHODS: We conducted a narrative review by searching several databases to identify studies published over the last decade that measured the response of blood, urine, and/or salivary biomarkers to variations (natural and intervention-induced) of changes in indoor air pollutant exposure. RESULTS: Numerous studies reported on associations between IAQ exposures and biomarkers with heterogeneity across study designs and methods. This review summarizes the responses of 113 biomarkers described in 30 articles. The biomarkers which most frequently responded to variations in indoor air pollutant exposures were high sensitivity C-reactive protein (hsCRP), von Willebrand Factor (vWF), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 1-hydroxypyrene (1-OHP). CONCLUSIONS: This review will guide the selection of biomarkers for translational studies evaluating the impact of indoor air pollutants on human health. Cambridge University Press 2020-09-04 /pmc/articles/PMC8057458/ /pubmed/33948261 http://dx.doi.org/10.1017/cts.2020.532 Text en © The Association for Clinical and Translational Science 2020 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Senerat, Araliya M.
Manemann, Sheila M.
Clements, Nicholas S.
Brook, Robert D.
Hassett, Leslie C.
Roger, Véronique L.
Biomarkers and indoor air quality: A translational research review
title Biomarkers and indoor air quality: A translational research review
title_full Biomarkers and indoor air quality: A translational research review
title_fullStr Biomarkers and indoor air quality: A translational research review
title_full_unstemmed Biomarkers and indoor air quality: A translational research review
title_short Biomarkers and indoor air quality: A translational research review
title_sort biomarkers and indoor air quality: a translational research review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057458/
https://www.ncbi.nlm.nih.gov/pubmed/33948261
http://dx.doi.org/10.1017/cts.2020.532
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