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Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis

Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the Hh-pathway in Drosophila. To investigate a possibl...

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Detalles Bibliográficos
Autores principales:	Mellis, David, Staines, Katherine A., Peluso, Silvia, Georgiou, Ioanna Ch., Dora, Natalie, Kubiak, Malgorzata, van’t Hof, Rob, Grillo, Michela, Farquharson, Colin, Kinsella, Elaine, Thornburn, Anna, Ralston, Stuart H., Salter, Donald M., Riobo-Del Galdo, Natalia A., Hill, Robert E., Ditzel, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057592/ https://www.ncbi.nlm.nih.gov/pubmed/33819267 http://dx.doi.org/10.1371/journal.pgen.1009275

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