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Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies

Transcriptome-wide association studies (TWAS) test the association between traits and genetically predicted gene expression levels. The power of a TWAS depends in part on the strength of the correlation between a genetic predictor of gene expression and the causally relevant gene expression values....

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Detalles Bibliográficos
Autores principales:	Feng, Helian, Mancuso, Nicholas, Gusev, Alexander, Majumdar, Arunabha, Major, Megan, Pasaniuc, Bogdan, Kraft, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057593/ https://www.ncbi.nlm.nih.gov/pubmed/33831007 http://dx.doi.org/10.1371/journal.pgen.1008973

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