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Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology

Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of...

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Autores principales: Anugwom, Chimaobi M., Allaire, Manon, Akbar, Sheikh Mohammad Fazle, Sultan, Amir, Bollipo, Steven, Mattos, Angelo Z., Debes, Jose D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057710/
https://www.ncbi.nlm.nih.gov/pubmed/33884303
http://dx.doi.org/10.20517/2394-5079.2021.06
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author Anugwom, Chimaobi M.
Allaire, Manon
Akbar, Sheikh Mohammad Fazle
Sultan, Amir
Bollipo, Steven
Mattos, Angelo Z.
Debes, Jose D.
author_facet Anugwom, Chimaobi M.
Allaire, Manon
Akbar, Sheikh Mohammad Fazle
Sultan, Amir
Bollipo, Steven
Mattos, Angelo Z.
Debes, Jose D.
author_sort Anugwom, Chimaobi M.
collection PubMed
description Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world.
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spelling pubmed-80577102021-04-20 Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology Anugwom, Chimaobi M. Allaire, Manon Akbar, Sheikh Mohammad Fazle Sultan, Amir Bollipo, Steven Mattos, Angelo Z. Debes, Jose D. Hepatoma Res Article Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world. 2021-03-26 2021 /pmc/articles/PMC8057710/ /pubmed/33884303 http://dx.doi.org/10.20517/2394-5079.2021.06 Text en https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Anugwom, Chimaobi M.
Allaire, Manon
Akbar, Sheikh Mohammad Fazle
Sultan, Amir
Bollipo, Steven
Mattos, Angelo Z.
Debes, Jose D.
Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
title Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
title_full Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
title_fullStr Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
title_full_unstemmed Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
title_short Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
title_sort hepatitis b-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057710/
https://www.ncbi.nlm.nih.gov/pubmed/33884303
http://dx.doi.org/10.20517/2394-5079.2021.06
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